Thyroid Disorders Community
Start Levothyroxine for hypothyroid, bipolar symptoms onset
About This Community:

This patient support community is for discussions relating to thyroid issues, goiter, Graves disease, Hashimoto's Thyroiditis, Human Growth Hormone (HGH), hyperthyroid, hypothyroid, metabolism, parathyroid, pituitary gland, thyroiditis, and thyroid Stimulating Hormone (TSH).

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Start Levothyroxine for hypothyroid, bipolar symptoms onset

Hi, I am not knowledgeable about thyroid disorders, but am hoping to get some information.  A good friend of the family (22 yr. old young man) was recently diagnosed with hypothyroidism, so was put on a dose of 50mcg of Levothyroxine.  After a week or so, he began exhibiting symptoms of mania, delusional thinking, and paranoia.  He saw the doctor who had prescribed the Levothyroxine, and told him how he was feeling.  the doctor sent him to the emergency room.  That night, he entered a psych hospital and has been there for 6 days.  

Doctors say he has had a manic episode, and are leaning towards diagnosing him with bipolar.  They're trying a couple anti-psychotic meds and plan to release him in six days.  

Perhaps not coincidentally, before and including the time he was taking the Levothyroxine, he had been stressed and sleep-deprived, working 16-hour days shoveling and plowing snow, not eating well, and using a lot of coffee and chewing tobacco to try to stay awake.  

What I am wondering is this:  Could his manic behavior, never even hinted at previously, be a side-effect of the Levothyroxine in combination with the other factors mentioned above?  

I should also mention that, for about a year and up until a year ago, he had been on 200mg of Zoloft, which, from what I understand, can push someone predisposed to bipolar into a manic episode, but he never exhibited any symptoms of mania during that time.  He's never had a suicidal low either.  

I hope I've explained this clearly. Thanks for any info you can provide!
3 Comments Post a Comment
Blank
1756321_tn?1377771734
Excerpt from Drugs Information Online - Levothyroxine 25 micrograms Tablets:

"Adverse effects of thyroid hormones are generally associated with excessive dosage and may not be apparent for several days after levothyroxine administration. Such effects normally resolve upon reduction of dosage or temporary withdrawal of the drug.

Cardiovascular tachycardia, palpitation, cardiac arrhythmias and anginal pain (see 4.4 Special warnings and precautions for use)

Gastrointestinal: Diarrhoea, vomiting.

General: Headache, flushing, sweating, fever, heat intolerance.

Immunological: Hypersensitivity reactions (rare) with rash, urticaria, angioedema, fever, eosinophilia or liver dysfunction.

Metabolic: Weight loss

Musculoskeletal: Muscular weakness and cramp. Craniosynostosis in infants and premature closure of the epiphyses in children.

Neurological: Nervousness, excitability, restlessness, insomnia, tremor. Rarely, pseudotumour cerebri (benign intracranial hypertension) in children.

Psychiatric disorders: levothyroxine may induce mania

Skin and subcutaneous tissue disorders: Levothyroxine can cause transient hair loss to occur in children.

Reproductive disorders: Menstrual irregularities."
Blank
Avatar_f_tn
Oh my goodness, what a difficult experience!  I don't know the answer but wanted to send encouragement your way.  I hope if it is coincidental and the mania is not related to meds, that he receives support he needs from his circle of friends and medical community as well, and if it is medicine induced, that medicine can be adjusted to keep this from happening again.  Best to all!

Blank
Avatar_m_tn
Thanks very much, both of you who responded.  He is getting out of the hospital tomorrow and then we will have a chance to speak with him and find out about his treatment plan.  Interesting to see the excerpt about Levothyroxine possibly inducing mania.  One would hope that the first order of treatment would be to look at that possibility and adjust that medication or change to another one (if possible).
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Thyroid Disorders Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank
233488_tn?1310696703
Blank
New Cannabis Article from NORTH Mag...
Jul 20 by John C Hagan III, MD, FACS, FAAOBlank
Top Thyroid Answerers
Avatar_m_tn
Blank
gimel
MI
649848_tn?1357751184
Blank
Barb135
FL
Avatar_f_tn
Blank
goolarra
Sisters, OR
168348_tn?1379360675
Blank
ChitChatNine
1756321_tn?1377771734
Blank
Red_Star
Queensland, Australia
657231_tn?1390151580
Blank
rumpled
Northern, NJ