I am presently titrating with Synthroid and have started taking 50 mcg. every other day (44 mcg. on the other days). My endocrynologist wants me to get to 80-100 mcg., but I'm working up very slowly to ward off the symptoms of nervousness. I'd like to understand what it means when on the days I take 50 mcg. I get way more fatigue & pain throughout my body than the days when I take 44 mcg. I'm wondering if it's because I need to be taking more Synthroid or if it's because my body is trying to tell me it's time to begin small doses of T3. Or do I need to back off & take 44 mcg. every day. Does anyone having any insight regarding these increased symptoms of fatigue/pain on the days I take a higher level of Synthroid?? // When I began traces of Synthroid several months ago it was like a total miracle for me. I felt as though I'd come alive; I had a brain again, the tendonitis in my hands & arms improved vastly along with my strength. Sleep came easier. It was simply amazing. And, now I'm feeling worse than I did before. I feel like I'm standing in concrete again. I've been diagnosed with Hashimotos. Thank you for any thoughts any one might have.