I have been taking 50mcg of Synthroid for the past month. Up from 25mcg from first diagnosis 3 months ago. Initial dose of synthroid, felt great. Lost the swelling in my legs, had energy. But after 3 weeks felt tired again. Upped to 50mcg. No real change and swelling has come back, along with thinnning hair and a new one - constipation which I never had, even pre treatment. Apart from that my temps have improved i feel (not taking them but feel a bit warmer). Anyone else find that increase synthroid not that good? Just went back for tests and will get results next week. Am thinking of adding cytomel or maybe even switching to Armor for a bit.