Thyroid Disorders Community
T4 to T3 conversion
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T4 to T3 conversion

I had an RAI ablation after being diagnosed with Grave's disease 10 years ago and have been on levothyroxine since.  Does synthetic T4 convert to T3?  I thought that T4 to T3 conversions occurred in the thyroid gland...so without one, where does this conversion take place?

Desperately need advice as I've been miserable when my TSH is in the "normal range" and have resorted to self-treatment.
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Although both T3 and T4 are produced in a healthy thyroid, far more T4 is produced than T3.  T4 is converted to T3 primarily in the liver, but the kidneys are also involved to a lesser extent as are other organs.  Yes, synthetic T4 does convert to T3, unless you are a "slow converter".  

Please post your free T3, free T4 (and their reference ranges) and TSH.  It sounds like you are either undermedicated or might require a bit of T3 meds if your FT3 and FT4 look out of balance.  It's difficult to comment further without seeing those.
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393685_tn?1325870933
I have about the same background as you with this disease. Grave's - then RAI

Goolaara is right on the mechanics of conversion.

I found it wasn't the right conversion for me as many do .

Until I found out my correct ratios of FT3 and FT4 I needed - I was lost - and sick too.

Get the labs.
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649848_tn?1357751184
It's usually not a good idea to self-medicate........what are you self medicating with? What are your most recent labs and were they done before or after you began self treating.

Please post your labs if you have them, along with dosage info.

I'm on both a T4 (levo) and T3 med because I wasn't converting enough T4 to T3.  Currently, doing well.
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