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Thyroglublin Antibody

Does anyone know what this is mine shows
<1.0 range 0.0-0.9 Low positive Thyroglobulin antibodies are seen in a portion of the asymptomatic populations.
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Avatar universal
Have you had TPOab tested (thyroid peroxidase antibody)?

TSI is in range, but the TSI test has a huge gray area.  The reference range says 0-139, because 139 is where most people start to experience symptoms.  However, people who don't have Graves', have TSI 0-2.  So, between 2 and 139, we have to figure something is going on, either just starting or going into remission.  Anyway, I'm glad you have that to take to the endo with you.

Of course, you don't have to have ALL the symptoms of hyper to be hyper, thank goodness, because the list is huge.  Do you have elevated HR or BP?  Increased appetite?  Insomnia?  

Do you have a U/S report to post?
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Avatar universal
Update on numbers
8/14/2014
TSH 0.220 range 0.490-4.670
Free T4 1.36 range 0.71-1.85
Free T3 3.33 range 2.30-4.20

after 5 weeks on methimazole
9/9/2014
TSH 0.796 range 0.490-4.670
Free T4 1.12 range 0.71-1.85
Free T3 2.95 range 2.30-4.20

Endo has decided to take me off meds for two weeks and then check my numbers again. I do have a small nodule and he has decided not to do Radioactive Iodine uptake to see if hot or cold. Said if numbers are good would just stay off meds and do nothing. If numbers change will do RAI.

What is your opinion on these numbers.

Thanks
Janet
Helpful - 0
Avatar universal
Not necessarily.  Graves' disease is far and away the biggest cause of hyper, but there are other causes as well.  Initial stages of Hashi's can be hyper or swing back and forth from hypo to hyper.  There are several types of "temporary" thyroiditis, including post-partum thyroiditis, deQuervain's thyroiditis and silent thyroiditis, all of which usually have an initial hyper phase, followed by a brief return to normal and a hypo phase.  Most of those are self-resolving, but all can become permanent.  As I mentioned above, a toxic nodule can also make you hyper.  I think that's all of them!  
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Avatar universal
No HR is good I check it all the time. lol, If you have a hyperthyroid does that necessarily mean you have Graves disease?
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Avatar universal
Neither TPOab nor TGab is significantly elevated, so your doctor will probably rule out Hashi's.

It depends on the nodules.  "Nodule" is a generic term that encompasses a lot of different "growths".  Nodules are very common in autoimmune thyroid disease, but they are the result of the disease, not the cause of the elevated thyroid hormones.  On the other hand, there are what are called "toxic nodules", and those are kind of like a mini-thyroid within your thyroid, and they do cause FT3 and FT4 to go up.  U/S will usually give an idea of which type you have, but more imaging might be required to pin it down completely.

HR is heart rate.  Hyper often causes fast heart rate.
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Avatar universal
Yes i have had the TPOab it showed 7 range is 0-34. Do you think having the thyroid nodules could be causing all these problems? I am on atenalol  but my doctor prescribed that for the anxiety also. I have mild high blood pressure and take amlidipine but have taken that for years. I do not have any kind of heart palpatations. And I am sorry not sure what HR is. THank you so much for all your help.
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Avatar universal
Oh and i was on 10mg methimazole
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Avatar universal
Yes my TSI was 24 range 0-139
The main reason he did thyroid testing was for the anxiety could not get rid of it. Still have it bad he is trying me on a anti depressent untill i get in with endo.
I have looked at smptoms of hyperthyroid I am not intolerant to heat, I stay cold all the time, anxiety, mood swings, and have lost 15 lbs in two months.
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Avatar universal
I'm guessing your doctor feels out of his element treating you, which is why he stopped your methimazole.  How much methimazole were you on?

How are you feeling?  Do you have a lot of hyper symptoms?  Please list them.

I'd suggest you ask your family doctor to order TSI (thyroid stimulating immunoglobulin).  TSI is the definitive test for Graves' disease (and by far most of hyper is Graves').  If you have that test in hand when you see the endo, it could save you some time in getting treatment.

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Avatar universal
I am currently set up in four weeks to see a endo.
First test results were
T4 free(direct) 1.68 range 0.82-1.77
TSH 0.221 range 0.450 to 4.400 they put me on methimazole but could not tolerate the medicine. They did not test my T3 at first visit.
Went back because the meds were making me very anxious.
Family doctor took me off meds and redid tests second results were
T3 3.59 range 2.00-4.00
T4 0.107 range 0.450-4.500
TSH 1.47
This was all done by my family doctor, also did Thyroid ultrasound and do have nodules on my Thyroid.
He took me off the methimazole but did not put me on anything else
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Avatar universal
It means that your thyroglobulin antibodies are a bit elevated.  Since they call this a "low positive", I'd have to assume that your actual result was between 0.9 and 0.99.

That is a very weak positive.  TGab is one of the markers for Hashi's, but just to give you some perspective, we often see antibody levels in the high hundreds, or even thousands, on diagnosis.  TGab can be somewhat elevated in Graves' as well and with some other autoimmune diseases and as your lab report states "are seen in a portion of the asymptomatic populations", i.e. some perfectly healthy people have a few.

Are you currently in the process of trying to diagnose your thyroid condition?  Has TPOab already been tested?  
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