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I have been on Synthroid for approx 15 years...last year I started having trouble with increased and/or pounding heart rate..not sleeping..increae anxiety..very hot. a recent tshPituitary and tsh Tsh was 0.43. I did not take SynthroiD 100mvg for 3 days because I forgot to pack it on a trip. On day three I felt better. Called DR (pcp) and he stopped it for approx 3 weeks. TSHPituitary and tsh Tsh was 16.50 but I felt 100% better. Restarted at 25mcg and after day 3 symptoms returned. Changed to generic brand and was told to start at 25mcg but I took only half the pill for 5 days with littleLittle noses decongestant Little tummys issues until I upped it to 25mcg. On day 2 symptoms return. Also have chest disocmfort with this. Waiting for endocrinology appt 6 weeks out. Why all the trouble after all these years and why am I having so much trouble with meds all of a sudden. I am a 50 year old femaleCondoms Female condoms Female sexual dysfunction who had Graves disease with RAI x2. Also PCP put me on Inderal 20 twice a day for tachy and palpatations last year because I could not take it anymore. Had a 30 day monitor and showed episodic tachycardia 110-140. Also can anyhting happen with a low TSH until I see endocrinologist