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What is Thyroid Peroxidase AB
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What is Thyroid Peroxidase AB

I had an ultrasound of my thyroid and blood work done recently.  My thyroid Peroxidase AB was very high at 715(what does this mean?), my free T4 is 1.3, my T3 is 115 and TSH ultrasensitive is .85.  I currently take .75 of Levoxyl.  My biggest complaint is weight gain.
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440728_tn?1234648902
The peroxidase is a thyroid antibody known as TPO I think, but I'm not sure. But raised antibodies in general show how much your thyroid is being attacked, and I think yours looks very high, but again I'm not quite sure. You need to wait for AR to see this post coz he's brill at this stuff. Did I get it right AR?
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I just received my lab work and my Thyroid Peroxidase (TPO) Ab <10 and Antithyroglobulin Ab Siemend (DPC) ICMA Methodology <20.  What does this mean
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213044_tn?1236531060
You got it right, Rite. LOL!!

Thyroid Peroxidase antibodies (TPOab) are an indication that you have an autoimmune disorder. 715 is rather high, and suggests strongly that it is a thyroid problem, as Rite760 said.

It is an antibody that can indicate either autoimmune hypothyroidism or autoimmune hyperthyroidism.

Autoimmune hypothyroidism is called Hashimoto's disease, and it is the most common form of hypothyroidism.

Autoimmune hyperthyroidism is called Grave's Disease, and if you have Grave's disease you will also have TSI antibodies.

Since you are taking Levoxyl, you have a history of hypothyroidism, and the presence of TPOab would change your diagnosis from "hypothyroid" to "Hashimoto's disease". It doesn't change your treatment, but it gives you a diagnosis of having an autoimmune disorder.


MaryBeth646,

Your two antibody tests came back negative, I believe. In other words, your antibody count on each test is below the upper limit, so it is considered as a result of zero.

You would have to look at your test results on the lab report and see what they use as an upper limit on each test. The upper limit for TPOab is usually 50 or 60, but lab ranges vary. The upper limit on TGab is usually 40, but again, you need to see what the upper limits are on your report.

Many people test "positive" to some degree on an antibody test. We all have these quirky rogue antibodies in very small numbers.

<10 means "less than 10". Not very specific, but as long as the number is below lab limit, 10 is considered zero.


TPOab that shows a low count, but above lab limit (positive) is also found in people with other types of autoimmune disease. If the upper limit is 60, and your result is 90, then it indicates an autoimmune condition of some type, but not particularly a thyroid problem.

It MAY be an autoimmune thyroid problem, or it may be Lupus, or Rheumatoid Arthritis, or one of several other autoimmune conditions. Evaluating symptoms and running further tests would be required to attribute that sort of TPOab level to a specific disease.  
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Thank you for responding...I was diagnosed with Hashimotos about 7 yrs. ago. My dad had a tyroid condition but not diagnosed until late in life, my son who is only 29 was diagnosed approximately 3 yrs. ago with a thyroid condition and I also have 2 neices with a thyroid condition, one has stopped taking medication and is doing well.  To my knowledge, I am the only one with Hashimotos.  I am having a difficult time getting weight off.  I use Levoxyl .075.(Should I change brands?)  All the relatives listed above are/were taking higher doses of of medication and don't seem to be having a weight issue.  I am a 54 yr. old female and I have gone through menopause.  My cholestrol goes up high and sometimes is down around 200 but I don't believe it has ever been lower than 200(I get an annual physical due to my occupation)(not on any cholestrol lowering meds).  I have had several surgeries due to tears in my tendons in knees, elbows basically all joints.  I presently have a tear in my left knee and 2 bakers cysts and working out can be challenging.  I had surgery on it in March and am not sure why I still have a tear. I also have celiac disease and arthritis.  I do not have RA as I was checked for it.  Any suggestions as to getting this weight off.  I have used diet pills off and on for yrs. with temporary success but DO NOT like how I feel when on them.  I read an article on an herb call "ashwagandha" which is suppose to help convert T4 into T3.  My doctor said not to mess with it.  While I was reading through some of these articles someone metioned injections that stimulate the thyroid.  Any input on that? I have a whole second half of my life to look forward to and I do not want to be overweight, please help. Thanks
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213044_tn?1236531060
I had a whole post written up and the stupid power flickered, and...had to reboot the computer.

I've been taking Levoxyl for three months. Before that I was taking Synthroid. I really haven't noticed any difference, although several people who switched from Synthroid to Levoxyl noticed an improvement. We're all a little different, I suppose.

Torn tendons. Do a search on tendon tear side effects. Two drugs pop up. Cipro and Levaquin.

I did a search on tendon tear, but all I got was sports injuries, not diseases. Not that I am a wizard at searching, but that's what I found.

I'm not familiar with the herb you mentioned. Some herbs are very beneficial. There are a lot of scammers that make promises they can't keep. It may help, or it may not.

I'm with your doctor. It you've had Hashimoto's for seven years, I think natural remedies may help a little, but in the end will just screw up your med dosage. Maybe optimizing your thyroid function so that you need less medication would be smart, but I would be afraid of stirring the pot, so to speak.

Your Celiac must make any sort of diet difficult. My sister has Celiac, and a normal diet is not possible for her, so dieting with the added restrictions you have must be very difficult.

Is it possible that you are slightly hypo much of the time and that is why you have the weight issue? Do you get tested every few months? Do your levels stay about the same from test to test? You list a T3 result, but where does that result fall on the test range that your lab uses? You really need a Free T3 test, and your level should be above midpoint on the lab range.

If your thyroid hormones are staying in a good place, then the weight may be a seperate issue. I wonder though if you have not been a little hypo lately, even though your TSH says not.  
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