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Wife's most recent labs

It has been a while since I posted about the progress of my wife.

She was on 150 mg of Armour (2.5 grains).

Her last labs came back and her TSH finally suppressed.  Surprised it took over 2 grains before the TSH got supressed.

TSH 0.062 (0.465-4.68)
FT4 0.67 (.78-2.19)  =  7.8 % BELOW range
FT3 4.02 (2.77-5.27) = 50% of the range

Please note that these reference ranges are wider than what is seen frequently.

This is the highest FT3 result she has EVER had.  Previous best with combo Levvo and cytomel was 3.65. But that endo retired and threw wife into thyroid tailspin until she found her current Dr who got back on the right track, albeit slowly but directionally correct.

Wife asked Dr. for another increase.  The Dr upped her dose from 150 mg to 165 mg (2.5 to 2.75 grains) Armour.

I was surprised that the DR raised it.  I was afraid that he would freak out by the suppressed TSH.  He had been bumping up at 0.5 grains (30 mg) prior.  The fact that he cut this bump to half suggests that he may be reaching his limit.

Personally I do not see a great number of hypo symptoms per say in my wife.  She is now warmer than I am more frequently in the car and in the house. I now am the one to have a sweat shirt on and click on the heat and she is the one who is opeing up the windows or turning the heat down.  So I think she is about at her FT3 limit.

I was in favor of adding bck in a smaller T4 dose and keeping the Armour at the 150 mg to try to get the FT4 up more into the normal range and shoot for increasing it slowly to get to about 50% of the FT4 range. and see how much if any converts for her.

We will see what this increase does.  If it proves too much.  she was able to get 15 mg tablets so all she has to do is stop taking that extra 15 mg pill.  Being T3 is fast acting the results would be pretty fast to back back down as well.

We are looking forward to getting this thyroid balanced out.  As my wife is also Low Testosterone and near bottom end Estrogen. But the Dr. will not do anything with the sex hormones until thyroid is stabalized.  Wife still has zero sex drive and the Low T may be a significant contributing factor to that.
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Avatar universal
I agree that it is time to move on.

I can only strongly suggest this to my wife to bring up with the Dr.  I can only bring a horse to water.  It is ultimately up to my wife to "fight" for this.

My wife is 45.  She has basically NEVER in 25 years of marriage had what I would call a sex drive.  For the last several years I/we had thought this may be due to her low thyroid condition and pursued and went through several Dr's trying to get her Hypo treated adequately.  But now that the thyroid is coming along and is I think fairly close to being optimized.  It has done very little if anything of a result related to libido.  And thus that leads into the whole Testosterone issue.

I realize that testosterone levels are far less for a women than a man.  And the ranges and information etc are based upon not only female but also based on phases of her cycle.  As a result the Dr prefers to test for sex hormones as soon after starting to menstrate as possible so there is some consistency from test to test.  And this makes sense.

The bottom line is that she is at or below the bottom of the range for  testosterone and her estrogen was significantly below range in one test and the next test which specifically tested Estradiol (as opposed to the listing of "estogen for the first test) was at 28% of the range.  I'm not sure those two tests were identical or apples to apples.  

I will have to do more study as to what are the symptoms of female low T other than low libido.

And one test that has not been done that I think would be important is to have her tested for DHEA.  I think that is a pre-cursor hormone for most if not all of the sex hormones. So if there is no base stock to make sex hormones, it would not be at all surprising that she would then be low in the sex hormones.
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649848 tn?1534633700
COMMUNITY LEADER
We all know that the hormones all have to work in sync with each other and if some are too low or even missing, we aren't going to feel well.  Of course, it's natural for some of them to decline as we age and to keep replacing some of them to levels we had when we were younger can be very detrimental; however, for someone as young as your wife, who has not gone through menopause to be deficient in all of the sex hormones, it would stand to reason that she should be treated, by now, with, at least low doses.

Women don't have/need nearly as much testosterone as men do, but we still need "some".  I know low testosterone in men causes muscle wasting, receding hair line, shuffling gait and other undesirable characteristics that make them old before their time - I haven't researched it in women all that much, but I'd assume it could contribute to the same issues.  Additionally, from my reading, testosterone is also the hormone that produces the most desire for sex, in both men and women.

I could see your wife's doctor wanting to work on thyroid hormones first, but it seems that it's time to move on and get everything else taken care of, as well.

As far as the type of hormones used, I suppose for every article you find that touts bio-identical, I can find one that says it's not necessary and visa versa, so that debate could on forever, just like the synthetic versus desiccated thyroid hormone debate.  There will be those, like myself that did/do fine on the synthetics (that's all that was available), just like I do fine on synthetic thyroid hormones and there will be those who wouldn't have anything but bio-identical hormone, just like there are those who refuse to take anything but desiccated thyroid hormones.

It doesn't really matter "why" her sex hormones got tested; the fact is, they did get tested and were found to be drastically out of whack, which unbalances the entire system.  If there's another doctor who might be willing to look at the situation, it might worth going out of your HMO just to see what he has to say.
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Avatar universal
Barb,

Wife does not forget too often her 2nd dose.  I think she does have an alarm on her phone..   They times she forgets are ususally times when we are doing something out of the routine like working outside all day and she doesn't have her phone and time simply flys by.  Then by the time she remembers it is later in day about dinner time which is then maybe too late and may keep her awake when she wants to go to bed/sleep.  She may miss her 2nd dose once or twice a month.

The sex hormone discussion you have above is interesting. An article, actually a whole chapter, provided by my wife's Dr. stated just the opposite. That in fact the synthetic hormones used were close to, but not exactly the same hormone the human body actually produced and uses.  Close but no cigar.  The article went on to state that the side effects and downsides including cancer and other "bad stuff" was dramatically higher with the synthetic commonly available hormones compared to using the exact hormone in the bioidentical form.

I believe the Dr was trying to simply pooh-pooh the whole idea of sex hormone replacement treatment but I don't know that for sure.  He just seemed a bit dubious and that article made apparently a pretty negative impression of HRT on him.  But Again my reading of it was that if there was a need when there is a proven deficiency, as long as you used the bioidentical and/or I suppose the exact hormone the downsides of remaining untreated outweighed any risks of being treated with HRT provided the treatment was proper and not over prescribed etc.

We also have a friend who is also suffering from Hypo and also sex hormone deficiency.  And the friends Dr is dealing with both at the same time and she is very happy with that Dr.  I'm pretty sure that Dr is outside our HMO but at least we may have a resource to go to and see if my wife's current Dr does not come on board with the whole idea of treating her low T and low Estrogen.

The sex hormones were initially tested actually to determine if my wife had estrogen dominance. Which can interfere with thyroid metabolism.  And much to our surprise she not only did NOT have estrogen dominance, she really has too low of estrogen and the Testosterone was VERY, VERY low.
Helpful - 0
649848 tn?1534633700
COMMUNITY LEADER
The first thing your wife needs to do is set an alarm (perhaps on her cell phone) so she doesn't forget that second dose of Armour.  The T4 will not keep her from wearing down later in the day as much as the second dose of Armour will.

I know all the rage is for bio-identical hormones, just like some people think desiccated thyroid hormones are the best because they're "natural".  I was on synthetic hormones, because when I needed them bio-identical didn't exist, but here's what Mayo Clinic says about bio-identical:

"Are "bioidentical" or "natural" hormones safer and more effective than hormones used in traditional hormone therapy for menopause symptoms?
Answers from Shannon K. Laughlin-Tommaso, M.D.

No, they aren't. According to the Food and Drug Administration (FDA) and several medical specialty groups, the hormones marketed as "bioidentical" and "natural" aren't safer than hormones used in traditional hormone therapy, and there's no evidence they're any more effective.

The term "bioidentical" means the hormones in the product are chemically identical to those your body produces. In fact, the hormones in bioidentical medications may not be any different from those in traditional hormone therapy. Several hormone therapy products approved by the FDA and prescribed by health care providers contain bioidentical hormones.

"Natural" means the hormones in the product come from plant or animal sources; they're not synthesized in a lab. However, many of these products still need to be commercially processed to become bioidentical.

Traditional hormone therapies don't necessarily exclude natural hormones. Some FDA-approved products — such as Estrace, Climara and Vivelle-Dot, which contain estrogens, and Prometrium, a natural progesterone — also are derived from plants.

Marketers of bioidentical hormones say their products have certain advantages over traditional hormone therapy:

    They're produced in doses and forms that differ from those in FDA-approved products. For many nonstandard combinations, you need to go through a compounding pharmacy — one that specializes in making medications customized for your individual needs. However, products from compounding pharmacies haven't been subject to the same rigorous quality assurance standards that standard commercially available hormonal preparations have to meet.
  
They're custom made for you, based on a test of your saliva to assess your unique hormonal needs. Unfortunately, however, the hormone levels in your saliva don't reflect the levels in your blood or correspond to menopause symptoms.

Some women may benefit from nonstandard doses and forms of hormones in bioidentical hormone preparations, but there is almost no scientific support for an advantage of these compounds over common commercially produced preparations."
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Avatar universal
My wife is NOT surgical menopause. In fact all other test show that while she is 45 years old is not really even showing signs much of premenopause.

I too have always believed that the Dr should be treating the low sex hormones.

She was tested twice.  

Teh first time her Testosterone was at ZERO percent of the range.  The second time she was BELOW range.

Estrogen the first time she was 22% BELOW range, the next time she was about 25% of the range.

Pregesterone was 58% and 25% of the range.

Both tests were very near identical in terms of timing of her cycle.  Within a couple of days of starting her period.

I agree that I think she needs these tested again AND include DHEA as well.

My wife had always converted T4 to T3 but very slowly.  The lack of Testosterone from discussion above may have been some of the issue perhaps.  My wife takes Selenium so that shouldn't be the issue.

I think Gimel supplied an article stating that the break down of T4 is used to make some sort of acid or enzyme that is used by the body to prevent tumors etc.  And this breakdown of T4 is the ONLY way that this acid is produced.  So I absolutely believe that it is important to have a sufficient supply of T4 for this as well as having "ready reserve" for possible conversion if the body needs it.

Occasionally my wife will forget to take her 2nd dose of Armour and then she fades in energy etc.  If she had some FT4 available she might not get so worn out if some could be converted.

My wifes feeling warmer than me has only recently begun with the bump from 2 to 2.5 grains of Armour. And may be a bit more noticable with this last 0.25 grain bump.  Although it has been only a few days since she has been on this dose.  So I think it is related to thyroid.

I know what i've read about sex hormone replacement that it is VERY important to make sure the replacement hormone is bio-identical. The synthetic hormones have huge side effects and are simply not as effective.

I would like to learn more about this as I think we will need ammunition to use to lobby the Dr. to convince to start the testosterone or DHEA or whatever to start working on that.  In addition to staring a dose of T4 medication.
Helpful - 0
649848 tn?1534633700
COMMUNITY LEADER
It's typical for people, including men, on Armour (or other desiccated hormones) to have very low FT4 because of the high potency of the T3 vs T4. Many/most, eventually, have to supplement the Armour (or other desiccated hormone) with additional T4.

In your case, it doesn't sound like you convert T4 to T3 adequately, so apparently,  you can either take the Armour and add a small amount of T4 med to keep your FT4 at about mid range or you can take the Synthroid and add a T3 med, such as cytomel to raise your FT3 to the upper half to upper third of its range. This isn't related to your menopausal status.

TSH is a very poor guide for whether one is hypo or not - many of us on any type of T3 med actually have suppressed TSH and can still be hypo. Hair loss is a hypo symptom and since it's not going away, your TSH of 2.5-3.0 is quite likely and indication that you're still hypo.  You might want to start your own thread and post your FT3 and FT4 levels as well, with reference ranges.  They simply may not be high enough for you.
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Avatar universal
Based on the low estrogen and testosterone, it sounds like your wife is in menopause. Is she by any chance in surgical menopause (ovaries removed) or hysterectomy induced menopause (failed ovaries)? The reason I ask is that is a different situation from natural menopause.

I am in surgical menopause :( and I have the same problem in that Armour and other dessicated thyroid meds increase my FT3 nicely but my FT4 stays at the bottom of the range even with a suppressed TSH. Synthroid raises my FT4 nicely and FT3 somewhat but it is still far too low. And the odd thing is that I do not feel much different on thyroid meds despite a TSH between 2.5 and 3.0 without meds. But my hair has been falling out for 9 years (since the surgery) and I was hoping thyroid meds were the answer especially with my strong family history of hypothyroidism. I am on estrogen and recently started taking a low dose of DHEA in hopes it will raise my testosterone and help my hair as well as libido!

Best of luck to your wife in getting settled on her hormones!
Helpful - 0
649848 tn?1534633700
COMMUNITY LEADER
I'm glad the doctor isn't freaking at the low TSH, as well.  I agree with adding some extra T4 and I also think it's time to start working on those reproductive hormones.  

From what I've read, low testosterone affects the way deiodinase 1 converts T4 to T3 in peripheral tissues, so if she "had" enough T4 for conversion, she might still not have proper conversion. DHEA is a precursor to testosterone, so that would be something else to look at.

The fact that your wife is now warmer than you are, could have to do with the lack of estrogen and progesterone... that's a very common symptom of peri-menopause.  I'm quite surprised that her doctor has left those hormones on the back burner for this long; all hormones in the body have to work together.
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Avatar universal
It is great that your wife has a doctor now that is actually willing to raise her Armour Thyroid dosage with that TSH.  Don't know if the 1/4 grain will be enough or not.  I do think she also needs to increase her Free T4 level beyond the effect from the 1/4 grain of Armour.  Free T4 needs to be at the middle of its range, at minimum,  Free T4 is important beyond just being available for conversion to T3.  
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Avatar universal
Hi, I can't comment on thyroid matters, but noticed you mentioned low estrogen/testosterone.  I am newly diagnosed with "regular" hypothyroid condition, and also low estrogen, and as the doctor put it, the testosterone level of an 80 year old woman.( soon to be 40)  I'm taking 1 grain of NT,  but he did prescribe the estrogen patch and testosterone and progesterone cream.  My estrogen levels have improved quite rapidly, in 6 weeks I was able to cut the dose in half,(from the highest dose available) some improvement from testosterone but not worth getting too excited about it. Since I'm at almost 0 testosterone will take a while for the level to get where it needs to be. Most likely he will increase the dose in 8 weeks when I go for a check up.  A good doctor should know how to help her navigate  with all the hormones she needs.  I personally don't think the thyroid will improve much on the sex hormones.  After 2 months of trial with thyroid meds and the other hormones I only see about 15% improvement.(in the sex dept.)  I would totally push to get estrogen and testosterone , progesterone  supplementation going. It takes time to get them to work on improving sex drive etc,. I'm also taking DHEA and pregnenolone, I was low on both. Good luck to both of you!
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