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difference levothyroxine vs. synthroid
My internist says that the generic form of Synthroid is exactly the same. I have heard from several medical friends that this is no so.  My Levothyroxine seems to not be making a difference.
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Many endos believe that generic levo is not the same as the brand names.  The reason they give for this is that generic can vary in its actual drug content by 10-15% from the nominal dosage.  That's one theory.  The other is that the big pharmaceutical companies have run a very successful smear campaign to discredit their competition and sell more of their higher-priced brand-name drugs.

I don't know who I believe, to tell you the truth.  However, if you've had success with Synthroid and feel better taking it, why not continue?  It's only a few dollars more expensive.

Some people react badly to the fillers of one brand name or another or the generic.

I've been on generic, Synthroid and Levoxyl at one time or another,  For me, I see absolutely no difference,.
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Thanks for the feed-back. I've been on 100mcg of Levothyroxine for a year or so and I still feel crappy. My TSH is .61 and I don't think I was ever told what my T4 is. Daughter has had her thyroid removed because of nodules and swears that there is a BIG difference between levothyroxine and Synthroid. Her Endocinologist has noted to the pharmacy to fill RX only! with Synthroid. That costs me $22 more a month. Really want to try Synthroid but my intenrist  says they are all the same. So it goes.....I've been looking for table or graphs on line with normal range levels and can't come up with one.
Any help there??? thanks again, framer
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Normal ranges are specific to your lab.  Different labs have different ranges...throw in different countries and different measurement units, and it all gets to be a major mess.  You have to either get the written lab report, which will have the reference ranges on it, or ask your doctor for the range if you get it verbally.

You have to get your FT4 (and its range) and FT3 (and range).  These are sooo much more important than TSH.  They are the actual thyroid hormones and indicate your thyroid status much better than TSH.

If you still feel crappy, you need your meds adjusted.  Synthroid vs. generic?  Maybe not so much.

My endo won't prescribe generic, either.  I'm not going to argue this point (there are so many others more worthy!), but when he switched me from generic to Levoxyl, my labs actually got worse.  I'm always suspicious of the pharmaceutical companies.  We moan and complain about oil industry profits, but they pale in comparison to pharmaceuticals.  The power of suggestion is enormous!
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There is actually a huge difference between Sythroid and the Generic Levothyroxine. I recently went through hell after using the generic, I had a major reaction to its fillers. I spent an entire month dizzy, vomiting, and had major migraines until I convinced my doctor that it was the medicine. He switched me to the brand name Synthroid and all the problems went away. According to most medical research the generic can change as much as 20% which can give you severe reactions, if you can get your doctor to prescribe you the Sythroid insist that the pharmacy gives it to you also. To me it was worth the extra $10-$12 a month it will cost me to make sure I get the same medicine each month.
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649848 tn?1424570775
My pcp INSISTED that I take nothing but synthroid, but my endo said it didn't make a difference.  I've been on generic levothyroxine, along with cytomel since January and although I still have some symptoms, I feel SO much better than I did on synthroid.  That's not to say synthroid wouldn't have eventually helped me to feel better, though - I believe my pcp was the problem there as he refused to consider any labs other than TSH and Free T4, then kept dropping my dosage based ONLY on TSH, in spite of the fact that my Free T4 was at the very bottom of the range or even sometimes below it.  

I agree with goolara though -  there are other, more worthy points to argue.  I think it depends on the individual and if you don't do well on one med, by all means switch to something else if your doctor will let you, but make sure you give each dosage change plenty of time to work, since it does take several weeks for a change to be effective.  
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Many people on this forum have also had a negative reaction to the fillers in Synthroid.  Some people simply cannot take it.  I don't think that reflects anything on the quality of the two products, but rather your own particular sensitivy to it.

Bear in mind that "most medical research" is paid for by the big drug companies and medical device manufacturers.  A lot more money is put into PR and advertising than research and development.  You know drug reps have been in all your doctors' offices.  All you have to see is the "free" samples of Synthroid and Levoxyl, etc. that they pass out.

Is the generic really inconsistent?  Or have Abbott (Synthroid) and King (Levoxyl) launched a massive  propaganda campaign to smear their competitors?  The same charges of inconsistency were lobbed against the brand names several years ago.  They have supposedly addressed their poroblems and now put out a superior product.  Call me a cynic.

Just food for thought...we all need to go with whatever works best for us.
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640719 tn?1277143630
I've been on Levothyroxine 8-9 years. My Endo told me he wanted me to take Levoxyl because he felt it was more of a reliable drug/dosing. I have made the change 3 times and each time within 3 days I have ended up with a serve stomach ache non stop. My Endo and Pharmacist tell me this can't be... That its the VERY SAME medicine. Hmmm... Tell my stomach that! I once rode it out for 2 weeks and I thought I was going to die with the pain. I told my daughter who is a dentist about this and she said she see's this happen with her patients all the time.. Same drug different companies different fillers causing re actions. Not sure why my Endo and Pharmacist keep telling me this. I'm sure I'm not the only one this has ever happened to! It can be frustrating to think how much they really don't know about a drug especially when my Edno comes highly recommended in the Thy community for my area.
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My Thyroid was removed about 30 years ago because of a goiter. For years I was taking Thyrolar II. My original doctor retired, which meant I started seeing a new doctor. The new doctor immediately took me off of the Thyrolar II and placed me on Synthroid.

Recently, my PCP lowered my Synthroid medication from 100mcg to 88mcg. He said my TSH was to low. My TSH level is 0.039, T4 is 10.7, T3 Uptake 32, and Free Thyroxine Index is 3.4.
Will someone tell me if my doctor was correct in lowering my medication?
I do not have any problems and I feel great, which is why I begged him not to change the level of the medication. About 10 years ago, I was taking synthroid 88mcg, but I was extremely fatigue and did not feel well. I do not want to feel that way again.
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No, your doctor was not correct.  Why would a change be necessary if you were feeling good?   Just because TSH is suppressed does not mean that you have become hyper, unless you do have hyper symptoms due to excessive levels of the biologically active thyroid hormones, Free T3 and Free T4.  

TSH is frequently suppressed when taking significant doses of thyroid meds.  For example, my TSH has been about .05 for well over 25 years without ever having hyper symptoms.  In fact, even with a high T4 level,  I continued to have hypo symptoms until I learned about the importance of FT3 and got my meds changed to add a source of T3.  Now I feel best ever.  And I am not the only one on the Forum with that experience.

This is a good link for you to discuss with your doctor.  It is written by a good thyroid doctor for patients that he is consulting with from a distance.   The letter is sent to the PCP of the patient, to help guide treatment.  Note his advice about TSH.

http://hormonerestoration.com/files/ThyroidPMD.pdf
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I went to the dr for bloodwork prior to surgery and found I was hypothyroid. For the last 18 months, I have gone every 3 for testing to see where my levels are at. I started at .25 and after a year I hit 112 mcg all the while being rx'd levo. My test in Mar showed my level was at 6.4 and I was again increased to 125. The pharmacy was out of levo and gave me synthroid. I just went last week for blood and my level was now over 9. Either they gave me a placebo, or some other phenomenon happened. Needless to say, I feel like I'm sleep walking everyday and have been upped to 150mcg. Lucky enough I was rx'd levo and got levo this time so we shall see in three months. Hope all is well on your end.

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I was glad to find your note. I have been so sick for a month with the same symptoms that you listed along with elevations in my BP and pulse.I had been on 75 mcgs of Synthroid for several yrs and a month ago my PCP must have forgot that my endo. had originally stated Synthroid only. I got my meds for the month and there was levothyroxine 50 instead of Synthroid. My PCP said that my labs were too high so he wanted me on 50. I just decided not to fight it and took the Levo. I am having difficulty functioning because of the severe headaches, dry heaves, dizziness, shortness of breath and vomiting. I decided not to take the levo for 3 days now and I seem like I feel a little better. The headache is still there but not migraine level. I have had several tests trying to determine the cause of the symptoms and have docs stumped. I am going to request the Synthroid back and hope that this resolves itself.  Thanks for sharing.
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You might want to post your recent labs with reference ranges.  Often doctors don't pay attention to the really important tests and make meds adjustments based on inappropriate or insufficient testing.  If you want to post those, we can help you interpret them.
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7991152 tn?1396065410
Hello the only thing I know to be true with me is; 6-7 years ago my doctor gave me levoxyl, generic for synthroid.  I don't remember now how long into taking levoxyl that I didn't feel right anymore.  I remember telling friends, family, doctor that something wasn't right, I felt like I was loosing my mind; crazy.  And everyone would say nothing is wrong and nothing was wrong even at doctors.  I never put it together with the change from synthroid to levoxyl. After about 1 1/2 - 2 yrs I came across a "pill" book at a friends house. I looked up synthroid and levoxyl and they were different.  And everything fell into place.  The dosages of some ingredients were not exact they were off by 10%.  I went to the docs and got on synthroid and I was able to tell a difference immediately.  So, I have been taking synthroid since.  Oh, I should add, I will be 47 in a month and was diagnosed with thyroid cancer when I was 22 yrs old. I had complete thyroidectomy and right neck dissection of lymph nodes.  Trust me I know it isn't the same and my understanding is it is like this in many generics vs. name brands but most don't notice.
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Levoxyl is NOT generic levothyroxine.  Levoxyl is another brand name, just like Synthroid, but from a different manufacturer.  Were you on Levoxyl or generic levothyroxine?  If you are prescribed Levoxyl, it's just like being prescribed Synthroid, and it always comes from the same manufacturer.  If you are prescribed generic levo, the pharmacy can change its supplier at any time, and you do not know where your next refill is coming from.

That being said, each manufacturer, generic and brand name, have minute differences in their tablets.  The difference is mostly in the fillers or inactive ingredients they use.  Some people do better on one than the other. That's why we always say that if you find one that works well for you, stick with it.

Dosages are allowed to vary within certain limits for all prescription drugs.  All that means is that you might have to adjust your dose slightly when transitioning from one to the other.  When I first saw my endo, I was on generic levo.  He doesn't like generics, so he switched me to Levoxyl.  My FT3 and FT4 actually went down a bit with that switch (same dose).  I'd been on 69 mcg of generic, and I had to go to 75 mcg Levoxyl.  




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When I was diagnosed they put me on levothyroxin, generic. I felt worse than before treatment. But I kept it up, because they say it takes awhile for your body to adjust. After over a year of feeling crappy, and only being able to sleep 3-4 hours at a time (I NEVER had trouble sleeping before!) I went to see an endocrinologist. His "solution" was to put me on an antidepressant. I refused! Neither of these doctors ever suggested just changing my meds. Trying something else. I finally found a good P.A. Who listened, and all she did was switch me to brand name Synthroid. I have been fine ever since! And have lost over 60 pounds since I feel so good!
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Many docs are wined and dined by the hot pharma reps so they will prescribe the brand name stuff.  Been diagnosed with hypothyroidism 20 years ago and I've been on both with zero difference. If you are a doc what is more important to you. Getting free lunches for you and your staff everyday (yes they do that at most clinics) or saving an insurance company money? A generic is the same active molecule(s) as the name brand. If not they'd have to get separate FDA approval through clinical trials.
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649848 tn?1424570775
Not everyone reacts to a medication in the same way and different manufacturers use different fillers, binders and dyes, which some people are sensitive or allergic to.  Additionally, some people may have absorption issues and can't handle a certain filler or binder, so while I agree with your statement that pharma often wines and dines doctors in order to get them to prescribe certain medications, a "good" doctor will look at all angles of the situation.  

Personally, I've been on Synthroid, a couple of generics, Tirosint and now Levoxyl... I did much better on generics than I did on Synthroid; I did better on Tirosint and am doing equally well on Levoxyl.  Most of the time, "if" one isn't sensitive/allergic to a filler/binder/dye it's a matter of getting the right dose and having the doctor being willing to add T3 med, if necessary.
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17076850 tn?1453513506
Barb is right about the fillers as my brother is lactose intolerant and many pill form medications have lactose as a partial filler. I have been switched from a higher dosage to a lower dosage of Synthroid a few times over the past few years. I've been on thyroid medication for about 30 years and recently I had an array of symptoms where I thought I had pneumonia because I was so weak and my chest felt like someone was sitting on it. My eyes felt like they were going to pop out of my skull and my heart was beating at 98+ bpm when I got out of bed in the morning. I don't like to "bother" my doctor as I have no insurance but I felt I should get an appt because I'm a single mom with a 13 year old daughter. This is the first time I noticed such a big change. Sure enough my TSH was high and my dose was lowered from 175mcg to 150 today. My blood tests were 2 days ago. I just noticed that the Rx says Synthroid/Levothyroxine sodium yet the tablets have "Synthroid" embossed on one side. I can't find out if these are a generic or the same Synthroid I've been taking for 30 years. A bit scared to try something new after the time I've had the past couple of 3-4 weeks.
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