Aa
elevated thyroglobulin
My son is 11 and has had a 45 IB weight gain in10 months he also has autism so I not sure on how he feels other then me noticing things, yes he has grown 3.5 inches but he looks so overweight. Our Dr. order TSH, T4, T3 free and a thyroglobulin. The TSH, T4, PTH, and free T3 have came back WNL but the Thyroglobulin came back elevated at 58.6. He also has done a 24 hour cortisol urine but waiting the results.
I felt his neck I don't feel a lump but why is his Thyroglobulin elevated. Can this be a false positive or does this mean........Cancer? I know thyroglobulin does not indicate cancer in all situations but am worried and just would like some advise.
-Thanks
I felt his neck I don't feel a lump but why is his Thyroglobulin elevated. Can this be a false positive or does this mean........Cancer? I know thyroglobulin does not indicate cancer in all situations but am worried and just would like some advise.
-Thanks
I forgot to add, i have a buffalo hump from severe insulin resistance. I had magnesium deficiency for over a decade. I keep developing magnesium deficiency very easily.
"Magnesium status is associated with insulin sensitivity (2, 3), and a low magnesium intake predicts the development of type II diabetes in most studies (4, 5) but not all (6). Magnesium supplements largely prevent diabetes in a rat model* (7). Interestingly, excess blood glucose and insulin themselves seem to reduce magnesium status, possibly creating a vicious cycle."
"Magnesium status is associated with insulin sensitivity (2, 3), and a low magnesium intake predicts the development of type II diabetes in most studies (4, 5) but not all (6). Magnesium supplements largely prevent diabetes in a rat model* (7). Interestingly, excess blood glucose and insulin themselves seem to reduce magnesium status, possibly creating a vicious cycle."
Correcting the gut issues as mentioned in step one was needed so the numerous nutrient deficiencies found could be corrected. But to add, hypothyroidism lowers stomach acid so there is yet another issue with absorption. The lab ranges you have listed are too low even for conventional "normal" ranges.
***
Excerpt from "B12 deficiency: a silent epidemic with serious consequences" by Chris Kresser...
"Why is B12 deficiency so under-diagnosed?
B12 deficiency is often missed for two reasons. First, it’s not routinely tested by most physicians. Second, the low end of the laboratory reference range is too low. This is why most studies underestimate true levels of deficiency. Many B12 deficient people have so-called “normal” levels of B12.
Yet it is well-established in the scientific literature that people with B12 levels between 200 pg/mL and 350 pg/mL – levels considered “normal” in the U.S. – have clear B12 deficiency symptoms. Experts who specialize in the diagnosis and treatment of B12 deficiency, like Sally Pacholok R.N. and Jeffery Stewart D.O., suggest treating all patients that are symptomatic and have B12 levels less than 450 pg/mL. They also recommend treating patients with normal B12, but elevated urinary methylmalonic acid (MMA), homocysteine and/or holotranscobalamin (other markers of B12 deficiency).
In Japan and Europe, the lower limit for B12 is between 500-550 pg/mL, the level associated with psychological and behavioral manifestations such as cognitive decline, dementia and memory loss. Some experts have speculated that the acceptance of higher levels as normal in Japan and the willingness to treat levels considered “normal” in the U.S. explain the low rates of Alzheimer’s and dementia in that country."
***
Excerpt from Vitamin D Council - "Am I vitamin D deficient?"...
"If having a doctor test your vitamin D levels, again, make sure the correct test is ordered - a 25-hydroxyvitamin D test. In addition, many doctors still consider a result of 30 ng/mL (75 nmol/L) to be sufficient when studies indicate otherwise."
"Studies indicate that for proper health, serum vitamin D levels should be a minimum of 50 ng/mL (125 nmol/L), with optimal levels falling between 50-80 ng/mL (125-200 nmol/L). These values apply to both children and adults."
***
Excerpt from "B12 deficiency: a silent epidemic with serious consequences" by Chris Kresser...
"Why is B12 deficiency so under-diagnosed?
B12 deficiency is often missed for two reasons. First, it’s not routinely tested by most physicians. Second, the low end of the laboratory reference range is too low. This is why most studies underestimate true levels of deficiency. Many B12 deficient people have so-called “normal” levels of B12.
Yet it is well-established in the scientific literature that people with B12 levels between 200 pg/mL and 350 pg/mL – levels considered “normal” in the U.S. – have clear B12 deficiency symptoms. Experts who specialize in the diagnosis and treatment of B12 deficiency, like Sally Pacholok R.N. and Jeffery Stewart D.O., suggest treating all patients that are symptomatic and have B12 levels less than 450 pg/mL. They also recommend treating patients with normal B12, but elevated urinary methylmalonic acid (MMA), homocysteine and/or holotranscobalamin (other markers of B12 deficiency).
In Japan and Europe, the lower limit for B12 is between 500-550 pg/mL, the level associated with psychological and behavioral manifestations such as cognitive decline, dementia and memory loss. Some experts have speculated that the acceptance of higher levels as normal in Japan and the willingness to treat levels considered “normal” in the U.S. explain the low rates of Alzheimer’s and dementia in that country."
***
Excerpt from Vitamin D Council - "Am I vitamin D deficient?"...
"If having a doctor test your vitamin D levels, again, make sure the correct test is ordered - a 25-hydroxyvitamin D test. In addition, many doctors still consider a result of 30 ng/mL (75 nmol/L) to be sufficient when studies indicate otherwise."
"Studies indicate that for proper health, serum vitamin D levels should be a minimum of 50 ng/mL (125 nmol/L), with optimal levels falling between 50-80 ng/mL (125-200 nmol/L). These values apply to both children and adults."
Hello,
your son seems to have malabsorption/ gut issues resulting in vitamin deviciencies:-
"My son's B-12 was checked last year and it was
189 ref range; 180-914
His riboflavin was 2 ref range; 3-15
His vit d 25 oh was 20 ref range; 25-80
The only thing I was told to do is to just keep doing what I already had been doing is giving him a muti-vit everyday."
I would think these deficiencies should be addressed agressively. He may also have others which haven't been found. I hope you could convince your new Dr to work with you on correcting these.
His Vitamin D is very low, he would need a D3 supplement. Probably at leat 5000 IUI/day (and retest in 3 months and then adjust further).
B12 is very low. This should be corrected - maybe high dose sublingual B12 if you can't get him injections to correct this.
You could look into "Gaps diet" Natasha Campbell which can help correct some of the gut issues.
Children with Autism often have genetic makeup which means they can't detox heavy metals and other toxins.
My nephew has been found to have very high blood mercury, lead and other heavy metals, even though he has never been vaccinated. His body just accumulates these and can't get rid of them.
your son seems to have malabsorption/ gut issues resulting in vitamin deviciencies:-
"My son's B-12 was checked last year and it was
189 ref range; 180-914
His riboflavin was 2 ref range; 3-15
His vit d 25 oh was 20 ref range; 25-80
The only thing I was told to do is to just keep doing what I already had been doing is giving him a muti-vit everyday."
I would think these deficiencies should be addressed agressively. He may also have others which haven't been found. I hope you could convince your new Dr to work with you on correcting these.
His Vitamin D is very low, he would need a D3 supplement. Probably at leat 5000 IUI/day (and retest in 3 months and then adjust further).
B12 is very low. This should be corrected - maybe high dose sublingual B12 if you can't get him injections to correct this.
You could look into "Gaps diet" Natasha Campbell which can help correct some of the gut issues.
Children with Autism often have genetic makeup which means they can't detox heavy metals and other toxins.
My nephew has been found to have very high blood mercury, lead and other heavy metals, even though he has never been vaccinated. His body just accumulates these and can't get rid of them.
After talking with the Dr. today she said that a TPOab is not needed to rule out Hashi's since his thyroglobulin AB was normal and that his other thyroid labs were within normal limits.
We are going to wait for the 24 hour urine results to come back- rule out cushing's due to the weight gain, moon face, and the small hump on his back that has developed since Jan, did not notice that until last week.
If the cortisol is normal then a thyroid U/S will be ordered and then I will need to make an appointment with the immuno dr that is 2 hours away
-thanks
We are going to wait for the 24 hour urine results to come back- rule out cushing's due to the weight gain, moon face, and the small hump on his back that has developed since Jan, did not notice that until last week.
If the cortisol is normal then a thyroid U/S will be ordered and then I will need to make an appointment with the immuno dr that is 2 hours away
-thanks
My son's B-12 was checked last year and it was
189 ref range; 180-914
His riboflavin was 2 ref range; 3-15
His vit d 25 oh was 20 ref range; 25-80
The only thing I was told to do is to just keep doing what I already had been doing is giving him a muti-vit everyday.
Thank You so much for the article. Stories like that make me smile.
-We have done the GFCF diet and all the supplementing for 2 years but only showed some improvement, more focused only slight communication/verbal improvement, and we could go in public without terrible melt downs. I have heard many wonderful stories about autism being cured but and please don't take this the wrong way in who ever reads this (This is only my opinion) but some kiddo's that are per say "cured" from autism don't really truly have that Diagnosis in the first place. I do believe that diet, supplements, very strick education plan with therapies can improve autism 100%, they definitely improve the individual but if they truly have autism they will not be "cured" from it.
Your talking with someone that started my child at the age of 2 right after the autism diagnosis in ABA therapy, OT therapy, Speech, therapy, diet change, music therapy, evaluations after evaluations, and the list goes on. The only thing I really wanted from my child is to be able to communicate with me but after 5 years of running from here to there and only seeing 50% improvement, in which in huge to me, I just had to give him a break. He is now 11 and we slowed down at age 7. We continue with some things but not as intense as before.
189 ref range; 180-914
His riboflavin was 2 ref range; 3-15
His vit d 25 oh was 20 ref range; 25-80
The only thing I was told to do is to just keep doing what I already had been doing is giving him a muti-vit everyday.
Thank You so much for the article. Stories like that make me smile.
-We have done the GFCF diet and all the supplementing for 2 years but only showed some improvement, more focused only slight communication/verbal improvement, and we could go in public without terrible melt downs. I have heard many wonderful stories about autism being cured but and please don't take this the wrong way in who ever reads this (This is only my opinion) but some kiddo's that are per say "cured" from autism don't really truly have that Diagnosis in the first place. I do believe that diet, supplements, very strick education plan with therapies can improve autism 100%, they definitely improve the individual but if they truly have autism they will not be "cured" from it.
Your talking with someone that started my child at the age of 2 right after the autism diagnosis in ABA therapy, OT therapy, Speech, therapy, diet change, music therapy, evaluations after evaluations, and the list goes on. The only thing I really wanted from my child is to be able to communicate with me but after 5 years of running from here to there and only seeing 50% improvement, in which in huge to me, I just had to give him a break. He is now 11 and we slowed down at age 7. We continue with some things but not as intense as before.
You might want to show this to your doctor:
"Thyroid Peroxidase (TPO) Antibodies (TPOAb) / Antithyroid Peroxidase Antibodies
Thyroid Peroxidase (TPO) antibodies, are also known as Antithyroid Peroxidase Antibodies. (In the past, these antibodies were referred to as Antithyroid Microsomal Antibodies or Antimicrosomal Antibodies). These antibodies work against thyroid peroxidase, an enzyme that plays a part in the T4-to-T3 conversion and synthesis process. TPO antibodies can be evidence of tissue destruction, such as Hashimoto's disease, less commonly, in other forms of thyroiditis such as post-partum thyroiditis.
It’s estimated that TPO antibodies are detectable in approximately 95 percent of patients with Hashimoto's thyroiditis, and 50 to 85 percent of Graves’ disease patients. The concentrations of antibodies found in patients with Graves' disease are usually lower than in patients with Hashimoto's disease.
Thyroglobulin Antibodies / Antithyroglobulin Antibodies
Testing for thyroglobulin antibodies (also called antithyroglobulin antibodies) is common. If you have already been diagnosed with Graves' disease, having high levels of thyroglobulin antibodies means that you are more likely to eventually become hypothyroid. Thyroglobulin antibodies are positive in about 60 percent of Hashimoto's patients and 30 percent of Graves' patients."
Since 95% of people with Hashi's are TPOab positive, but only 60% are TGab positive, testing only for TGab would seem to miss about 35% of the people with Hashi's. Many doctors only test TPOab to confirm or rule out Hashi's. A positive TPOab result confirms, but a negative does not rule out as some with Hashis are only TGab positive. I think you have to test for both, but were you to choose one, it would be TPOab.
"After talking with the Dr. today she said that a TPOab is not needed to rule out Hashi's since his thyroglobulin AB was normal and that his other thyroid labs were within normal limits."
Just because TGab is normal does not mean a thing. Many of us with Hashi's are only TPOab positive. One does not correlate with the other at all. AI diseases run in families (not necessarily the SAME AI), so with his family history, your son's doctor ought to be being thorough on this point. Do you have Hashi's?
As I said above, many of us find that hypo symptoms persist until FT4 is around 50% of range. Your son's is 17% of range...very low and where most of us would feel very hypo. Ranges are very flawed for a number of reasons, and good thyroid doctors recognize that just being on the bottom of the range is seldom sufficinet to make us well.
If I were you, I think I'd start by very strongly (as in not taking no for an answer) asking for TPOab. Total T3 is also on the low side, and total's usefulness is limited. He needs FT3 (along with a repeat of FT4 and TSH).
"Thyroid Peroxidase (TPO) Antibodies (TPOAb) / Antithyroid Peroxidase Antibodies
Thyroid Peroxidase (TPO) antibodies, are also known as Antithyroid Peroxidase Antibodies. (In the past, these antibodies were referred to as Antithyroid Microsomal Antibodies or Antimicrosomal Antibodies). These antibodies work against thyroid peroxidase, an enzyme that plays a part in the T4-to-T3 conversion and synthesis process. TPO antibodies can be evidence of tissue destruction, such as Hashimoto's disease, less commonly, in other forms of thyroiditis such as post-partum thyroiditis.
It’s estimated that TPO antibodies are detectable in approximately 95 percent of patients with Hashimoto's thyroiditis, and 50 to 85 percent of Graves’ disease patients. The concentrations of antibodies found in patients with Graves' disease are usually lower than in patients with Hashimoto's disease.
Thyroglobulin Antibodies / Antithyroglobulin Antibodies
Testing for thyroglobulin antibodies (also called antithyroglobulin antibodies) is common. If you have already been diagnosed with Graves' disease, having high levels of thyroglobulin antibodies means that you are more likely to eventually become hypothyroid. Thyroglobulin antibodies are positive in about 60 percent of Hashimoto's patients and 30 percent of Graves' patients."
Since 95% of people with Hashi's are TPOab positive, but only 60% are TGab positive, testing only for TGab would seem to miss about 35% of the people with Hashi's. Many doctors only test TPOab to confirm or rule out Hashi's. A positive TPOab result confirms, but a negative does not rule out as some with Hashis are only TGab positive. I think you have to test for both, but were you to choose one, it would be TPOab.
"After talking with the Dr. today she said that a TPOab is not needed to rule out Hashi's since his thyroglobulin AB was normal and that his other thyroid labs were within normal limits."
Just because TGab is normal does not mean a thing. Many of us with Hashi's are only TPOab positive. One does not correlate with the other at all. AI diseases run in families (not necessarily the SAME AI), so with his family history, your son's doctor ought to be being thorough on this point. Do you have Hashi's?
As I said above, many of us find that hypo symptoms persist until FT4 is around 50% of range. Your son's is 17% of range...very low and where most of us would feel very hypo. Ranges are very flawed for a number of reasons, and good thyroid doctors recognize that just being on the bottom of the range is seldom sufficinet to make us well.
If I were you, I think I'd start by very strongly (as in not taking no for an answer) asking for TPOab. Total T3 is also on the low side, and total's usefulness is limited. He needs FT3 (along with a repeat of FT4 and TSH).
I know all about spacing out unfortunately. I've had vitamin B12 malabsorption for decades. My niece and nephew both exhibited autistic symptoms for a year after an MMR vaccine. I read a very interesting article from Dr Mark Hyman entitled "Why Current Thinking About Autism Is Completely Wrong". The article is amazing. B12 deficiency...i see you!
"Sam's Roadmap to Recovery: A Model for Treating Autism
Step 1: Fix His Gut and Cool the Inflammation There
This step included a number of different tactics including:
• Taking away gluten and other food allergens
• Getting rid of his yeast with anti-fungals
• Killing off the toxic bacteria in his small intestine with special antibiotics
• Replenishing healthy bacteria with probiotics
• Helping him digest his food with enzymes
Step 2: Replace the Missing Nutrients to Help His Genes Work Better
In Sam's case we:
• Added back zinc, magnesium, folate, and vitamins A, B6, B12, and D
• Supported his brain with omega-3 fats
Step 3: Detoxify and Reduce Oxidative Stress
• Once his biochemistry and nutrition was tuned up, we helped him detoxify and reduce oxidative stress.
Improve nutrition, reduce inflammation, heal the gut, detoxify -- this should sound familiar.
As I said before, the keys of UltraWellness can help, no matter what the disease or condition. You see, biology has basic laws, which we have to follow and understand. All the details of Sam's story fit into these laws. We just have to dig deep, peel back the layers, and understand what is going on. When we do this the results are nothing short of miraculous ...
After following a gluten-free diet and treating his gut for 3 weeks, Sam showed dramatic and remarkable improvement. He's getting back much of his language skills and showing much more connection and relatedness in his interactions.
After 4 months, he was more focused, unstuck and verbal.
After 10 months, his bowels were back to normal, he was verbally fluent, mainstreamed in school and he "lost" his diagnosis of autism."
"Sam's Roadmap to Recovery: A Model for Treating Autism
Step 1: Fix His Gut and Cool the Inflammation There
This step included a number of different tactics including:
• Taking away gluten and other food allergens
• Getting rid of his yeast with anti-fungals
• Killing off the toxic bacteria in his small intestine with special antibiotics
• Replenishing healthy bacteria with probiotics
• Helping him digest his food with enzymes
Step 2: Replace the Missing Nutrients to Help His Genes Work Better
In Sam's case we:
• Added back zinc, magnesium, folate, and vitamins A, B6, B12, and D
• Supported his brain with omega-3 fats
Step 3: Detoxify and Reduce Oxidative Stress
• Once his biochemistry and nutrition was tuned up, we helped him detoxify and reduce oxidative stress.
Improve nutrition, reduce inflammation, heal the gut, detoxify -- this should sound familiar.
As I said before, the keys of UltraWellness can help, no matter what the disease or condition. You see, biology has basic laws, which we have to follow and understand. All the details of Sam's story fit into these laws. We just have to dig deep, peel back the layers, and understand what is going on. When we do this the results are nothing short of miraculous ...
After following a gluten-free diet and treating his gut for 3 weeks, Sam showed dramatic and remarkable improvement. He's getting back much of his language skills and showing much more connection and relatedness in his interactions.
After 4 months, he was more focused, unstuck and verbal.
After 10 months, his bowels were back to normal, he was verbally fluent, mainstreamed in school and he "lost" his diagnosis of autism."
This is great. I have also read on all of this.
OK- here's my story and my son's health issues that have been brushed aside.
Born- to a mother (me) at 34 weeks-premature-
-premature dialation at 28 weeks bed rest until 30 weeks
- developed HTN started at 30 weeks preg bed rest again 32 weeks
until I had premature rupture of membrains that was a slow leak for
3 days and was unaware
-started pit at 3 pm and then only dilated to 8 cm by 11pm.
- ended with C-section at 1:35 am; he was sunny side up.
- AGAR normal right away but then developed breathing issues and
became tacky
- Had sepsis and areas on the lungs that showed pneumonia
- c-pap for 4 days then O2 for 4 days after c-pap was d/c.
- IV antibiotics and became jaundice.
- was in ICU for 14 days
Then improved after coming home.
At 3 months he got RSV mild but treated, he then got RSV at 5 months, again at 8 months, and 11 months.
Had some infections, ear infections in between the RSV.
He did also have a time with his tummy(lots of spitting up) and constipation starting around 3 months. He also had Thrush so bad for 2 months at 2 months of age.
We seen a cardiologist at 8 months due to his lips and hands turning blue and they DX at that time with Asthma due to that recurrent RSV issues.
OK- then at age one had neuromas throat infections-strep-tonsillitis, and occasional ear infections. Treated with antibiotics a lot during this time.
At 20 months started noticing bizarre behaviors and quit verbalizing.
DX with PDD-NOS (autism) at 2 years old.
The illnesses continued.
Then at 4 he started have these weird stare off spells, that have been ruled out as seizures and has only had 1 or 2 in the last 18 months.
At age 9 he started urinated all the time 7 to 8 times in 1 hour. went to his family dr on lots of occasions with this and UTI's were always ruled out, but the UA's would show small protein, Urogl, blood, bilirubin, and a few times ketones. Diabetes was ruled out after the testing cleared him of that.
then referred to a neurologist and he did a bunch of labs to check for metabolic but all came back within normal limits. The only test that was done and came back low at that time which was in 2011 was his creatine not creatinine but creatine.
He has had muscle weakness for 2 years.
So we were referred to a bigger and better hospital and that's when the immuo issue raised and the genetics dr did find a introversion or something like that with 23.
our health ins with not cover this for my husband an I to be checked so it has not been done. If my husband or I have that same inversion at 23 then we know it just part of our make up but if neither of us have it than we know why Brandon is having so many issues.
This thyroid thing is new due to this huge weight gain issue. over the last [10 months and now this weird rash.
After talking with the Dr. today she said that a TPOab is not needed to rule out Hashi's since his thyroglobulin AB was normal and that his other thyroid labs were within normal limits.
We are going to wait on the 24 hour urine cortisol to rule out cushing's due to the weight gain, moon face, and the small hump on his back that has developed since Jan, did not notice that until last week.
If the cortisol is normal then a thyroid U/S will be ordered and then I will need to make an appointment with the immuno dr that is 2 hours away.
This has been great information. I feel like nothing is ever taken care of and then I hold off and the support system that I have is not very supportive. Bottom line is I have a child with Moderate to severe autism that is nonverbal and I know when things are not right with him. I am his mother and that is my job is to make sure that he feels good.
-THANK YOU ALL
Also I have Hypothyroidism and my husband has been DX with antiphospholipid syndrome and still ? lupus. He has had 3 pos Lupus anticog and 3 pos ANA's and his rheumatologist is not very good and so now the dr has discouraged my husband and he will not return to the dr for follow up he has not been back for 2 years. That's a whole nother story.
Wow!!!
OK- here's my story and my son's health issues that have been brushed aside.
Born- to a mother (me) at 34 weeks-premature-
-premature dialation at 28 weeks bed rest until 30 weeks
- developed HTN started at 30 weeks preg bed rest again 32 weeks
until I had premature rupture of membrains that was a slow leak for
3 days and was unaware
-started pit at 3 pm and then only dilated to 8 cm by 11pm.
- ended with C-section at 1:35 am; he was sunny side up.
- AGAR normal right away but then developed breathing issues and
became tacky
- Had sepsis and areas on the lungs that showed pneumonia
- c-pap for 4 days then O2 for 4 days after c-pap was d/c.
- IV antibiotics and became jaundice.
- was in ICU for 14 days
Then improved after coming home.
At 3 months he got RSV mild but treated, he then got RSV at 5 months, again at 8 months, and 11 months.
Had some infections, ear infections in between the RSV.
He did also have a time with his tummy(lots of spitting up) and constipation starting around 3 months. He also had Thrush so bad for 2 months at 2 months of age.
We seen a cardiologist at 8 months due to his lips and hands turning blue and they DX at that time with Asthma due to that recurrent RSV issues.
OK- then at age one had neuromas throat infections-strep-tonsillitis, and occasional ear infections. Treated with antibiotics a lot during this time.
At 20 months started noticing bizarre behaviors and quit verbalizing.
DX with PDD-NOS (autism) at 2 years old.
The illnesses continued.
Then at 4 he started have these weird stare off spells, that have been ruled out as seizures and has only had 1 or 2 in the last 18 months.
At age 9 he started urinated all the time 7 to 8 times in 1 hour. went to his family dr on lots of occasions with this and UTI's were always ruled out, but the UA's would show small protein, Urogl, blood, bilirubin, and a few times ketones. Diabetes was ruled out after the testing cleared him of that.
then referred to a neurologist and he did a bunch of labs to check for metabolic but all came back within normal limits. The only test that was done and came back low at that time which was in 2011 was his creatine not creatinine but creatine.
He has had muscle weakness for 2 years.
So we were referred to a bigger and better hospital and that's when the immuo issue raised and the genetics dr did find a introversion or something like that with 23.
our health ins with not cover this for my husband an I to be checked so it has not been done. If my husband or I have that same inversion at 23 then we know it just part of our make up but if neither of us have it than we know why Brandon is having so many issues.
This thyroid thing is new due to this huge weight gain issue. over the last [10 months and now this weird rash.
After talking with the Dr. today she said that a TPOab is not needed to rule out Hashi's since his thyroglobulin AB was normal and that his other thyroid labs were within normal limits.
We are going to wait on the 24 hour urine cortisol to rule out cushing's due to the weight gain, moon face, and the small hump on his back that has developed since Jan, did not notice that until last week.
If the cortisol is normal then a thyroid U/S will be ordered and then I will need to make an appointment with the immuno dr that is 2 hours away.
This has been great information. I feel like nothing is ever taken care of and then I hold off and the support system that I have is not very supportive. Bottom line is I have a child with Moderate to severe autism that is nonverbal and I know when things are not right with him. I am his mother and that is my job is to make sure that he feels good.
-THANK YOU ALL
Also I have Hypothyroidism and my husband has been DX with antiphospholipid syndrome and still ? lupus. He has had 3 pos Lupus anticog and 3 pos ANA's and his rheumatologist is not very good and so now the dr has discouraged my husband and he will not return to the dr for follow up he has not been back for 2 years. That's a whole nother story.
Wow!!!
Serum Tg reflects abnormalities in thyroid mass, excessive thyroidal stimulation, or physical damage to the thyroid secondary to surgery, Fine Needle Aspiration biopsy (FNA) or thyroiditis.
With differentiated thyroid carcinoma, the serum Tg reflects thyroid mass (tumour or normal remnant), thyroid injury (surgery or FNA) and TSH receptor stimulation (endogenous or rhTSH).
With differentiated thyroid carcinoma, the serum Tg reflects thyroid mass (tumour or normal remnant), thyroid injury (surgery or FNA) and TSH receptor stimulation (endogenous or rhTSH).
Autism Research Institute - Immune Function & ASD...
"Is There a Connection Between Immune Function and Autism?
The ideal immune system will:
* Recognize all foreign organisms (bacteria, viruses, parasites, fungi, worms).
* Efficiently and rapidly destroy invaders.
* Prevent a second infection with the same microbe (have a good memory).
* Never cause damage to self.
Things that can go wrong:
* Immune deficiency/dysfunction: defective or ineffective response.
* Hypersensitivity: Over-reaction to innocuous foreign material, out of proportion to potential damage (allergy).
* Autoimmunity: Inappropriate reaction towards self, loss of self-recognition.
* Inflammation: Too-vigorous attack against invaders with “bystander” damage to normal tissue.
Dysregulation of immunity in people with autism can lead to any of these four problems.
There is a tendency towards a positive family history of autoimmunity in families – Rheumatoid Arthritis, Thyroiditis - with an ASD child. Many, many types of autoantibodies (against “self” tissues) have been found in ASD children but the significance of the many types of anti-brain antibodies is not yet clear.
Several studies find that some ASD children have low immunoglobulins (IgG, IgM, IgA), and/or low T cell numbers, altered cytokine profiles, and/or low-normal functioning and/or low NK cells; a subset of children have true immunodeficiency. Some children have low serum IgA, predisposing them to respiratory and GI infections.
Antibodies are divided up into classes:
IgA: Mucosal surfaces - if this is low, it predisposes to respiratory and GI infections as well as autoimmunity; it is sometimes low in ASD children
IgM: Rapid response bloodstream antibody made at the beginning of an infection; can be high or low in ASD
IgG: Slower but longer lasting bloodstream antibody; can be high or low in ASD
IgE: Allergy; can be high or normal in ASD
Conclusion #1: A child on the autism spectrum with recurrent infections deserves an immune evaluation for immunodeficiency.
Conclusion #2: A child on the autism spectrum with eczema, chronic nasal symptoms, asthma, significant GI symptoms, or recurrent respiratory infections deserves an allergy evaluation for IgE inhalant and food allergies."
"Is There a Connection Between Immune Function and Autism?
The ideal immune system will:
* Recognize all foreign organisms (bacteria, viruses, parasites, fungi, worms).
* Efficiently and rapidly destroy invaders.
* Prevent a second infection with the same microbe (have a good memory).
* Never cause damage to self.
Things that can go wrong:
* Immune deficiency/dysfunction: defective or ineffective response.
* Hypersensitivity: Over-reaction to innocuous foreign material, out of proportion to potential damage (allergy).
* Autoimmunity: Inappropriate reaction towards self, loss of self-recognition.
* Inflammation: Too-vigorous attack against invaders with “bystander” damage to normal tissue.
Dysregulation of immunity in people with autism can lead to any of these four problems.
There is a tendency towards a positive family history of autoimmunity in families – Rheumatoid Arthritis, Thyroiditis - with an ASD child. Many, many types of autoantibodies (against “self” tissues) have been found in ASD children but the significance of the many types of anti-brain antibodies is not yet clear.
Several studies find that some ASD children have low immunoglobulins (IgG, IgM, IgA), and/or low T cell numbers, altered cytokine profiles, and/or low-normal functioning and/or low NK cells; a subset of children have true immunodeficiency. Some children have low serum IgA, predisposing them to respiratory and GI infections.
Antibodies are divided up into classes:
IgA: Mucosal surfaces - if this is low, it predisposes to respiratory and GI infections as well as autoimmunity; it is sometimes low in ASD children
IgM: Rapid response bloodstream antibody made at the beginning of an infection; can be high or low in ASD
IgG: Slower but longer lasting bloodstream antibody; can be high or low in ASD
IgE: Allergy; can be high or normal in ASD
Conclusion #1: A child on the autism spectrum with recurrent infections deserves an immune evaluation for immunodeficiency.
Conclusion #2: A child on the autism spectrum with eczema, chronic nasal symptoms, asthma, significant GI symptoms, or recurrent respiratory infections deserves an allergy evaluation for IgE inhalant and food allergies."
Oh my-thank you this has helped so much.
Not for sure if the eczema is autoimmune but it is sure looking more and more like and autoimmune rash. I think we need to see dermatology.
Not for sure if the eczema is autoimmune but it is sure looking more and more like and autoimmune rash. I think we need to see dermatology.
Although labs are in range, FT4 is way too low in range. Many of us find we have symptoms until FT4 is about midrange (50%), and your son's is only at 17% of range. Unfortunately, they ran a TT3, not and FT3. TT3 tells the total amount of T3 in the blood, but much of that is attached to protein and unavailable to cells. FT3 tells what's available.
I'd have them check TPOab. Almost everyone who has Hashi's is TPOab positive. Only a few are TGab positive. Yes, if we have one autoimmune, we are more likely to get a second than the general population is to get their first. What the connection is sin't known, but it's pretty obvious there is one.
Is the eczema considered autoimmune?
I'd have them check TPOab. Almost everyone who has Hashi's is TPOab positive. Only a few are TGab positive. Yes, if we have one autoimmune, we are more likely to get a second than the general population is to get their first. What the connection is sin't known, but it's pretty obvious there is one.
Is the eczema considered autoimmune?
thank you for the information.
Here is the other thyroid function lab levels.
T3 Total; 146 ref range 94-213
T4 free; 1.02 ref range 0.78-2.19
TSH; 2.08 ref range 0.46-4.70
PTH intact; 26 ref range 11-74
He does have IgA def and IgM def; We found this out last year.
His IgA was a "3" ref range 42-295
IgM was "35" ref range 41-255
IgG was normal at "1190" ref range 503-1719
He has had his TSH level now on 3 different occasions.
2/12 TSH was "2.0" ref range 0.3-5.0
7/2011 TSH was "2.03" ref range 0.6-5.5
9/2010 TSH was "4.29" done at same hospital lab as a few days ago
ref range;0.46-4.70
The lab thyroid peroxidase antibodies were not done and a thyroid u/s has not yet been done but was planning on having that scheduled after talking with the Dr. tomorrow.
With the Immuno deficiency one would be suspicious of Hashi's??? The Dr was see for that did say he would be more at risk for an autoimmune issue.
So many weird things with my child. Never had a weight issue until 10 months ago. His diet is so slim with the choices of the foods he does eat I just can't figure out this weight gain issue. I know hormones can do that but man 45 Ibs is a lot and he does not look healthy either. We seen the immune dr last year before the weight started coming on. He also has an, at last this is what I was told, eczema all over his upper arms and lower arms, cheeks, chest, and some now starting on his back. He's always had a little but it has gotten much worse over the last month.
Ok I'm done.
Thank you again!!! :)
Here is the other thyroid function lab levels.
T3 Total; 146 ref range 94-213
T4 free; 1.02 ref range 0.78-2.19
TSH; 2.08 ref range 0.46-4.70
PTH intact; 26 ref range 11-74
He does have IgA def and IgM def; We found this out last year.
His IgA was a "3" ref range 42-295
IgM was "35" ref range 41-255
IgG was normal at "1190" ref range 503-1719
He has had his TSH level now on 3 different occasions.
2/12 TSH was "2.0" ref range 0.3-5.0
7/2011 TSH was "2.03" ref range 0.6-5.5
9/2010 TSH was "4.29" done at same hospital lab as a few days ago
ref range;0.46-4.70
The lab thyroid peroxidase antibodies were not done and a thyroid u/s has not yet been done but was planning on having that scheduled after talking with the Dr. tomorrow.
With the Immuno deficiency one would be suspicious of Hashi's??? The Dr was see for that did say he would be more at risk for an autoimmune issue.
So many weird things with my child. Never had a weight issue until 10 months ago. His diet is so slim with the choices of the foods he does eat I just can't figure out this weight gain issue. I know hormones can do that but man 45 Ibs is a lot and he does not look healthy either. We seen the immune dr last year before the weight started coming on. He also has an, at last this is what I was told, eczema all over his upper arms and lower arms, cheeks, chest, and some now starting on his back. He's always had a little but it has gotten much worse over the last month.
Ok I'm done.
Thank you again!!! :)
Thanks for the clarification.
Did they also test TPOab (thyroid peroxidase antobodies)? They're the other, and more prevalent markers for Hashi's.
Elevated TG is characteristic of other forms of thyroiditis, specifically silent or subacute thyroiditis. Silent is usually characterized by an initial hyper phase, a brief return to normal, followed by a hypo phase that is "temporary". Although temporary, it can last a couple of years, so it sometimes needs the support of thyroid meds until it resolves.
The TG test really doesn't give any information about cancer as a one time, stand alone test. It's only in series that it's useful in identifying thyroid cancer. If someone has a cancer that elevates TG and they're treated with surgery and/or RAI, the TG level will usually go down over time. Once that has happened, TG can be used to monitor recurrence.
Would you post the other thyroid test results and ranges?
Has his doctor ordered a thyroid ultrasound?
Did they also test TPOab (thyroid peroxidase antobodies)? They're the other, and more prevalent markers for Hashi's.
Elevated TG is characteristic of other forms of thyroiditis, specifically silent or subacute thyroiditis. Silent is usually characterized by an initial hyper phase, a brief return to normal, followed by a hypo phase that is "temporary". Although temporary, it can last a couple of years, so it sometimes needs the support of thyroid meds until it resolves.
The TG test really doesn't give any information about cancer as a one time, stand alone test. It's only in series that it's useful in identifying thyroid cancer. If someone has a cancer that elevates TG and they're treated with surgery and/or RAI, the TG level will usually go down over time. Once that has happened, TG can be used to monitor recurrence.
Would you post the other thyroid test results and ranges?
Has his doctor ordered a thyroid ultrasound?
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