hashi, or something more?

[tg45]

I have been hypothyroid for over 20 years and on Synthroid.  I was just recently tested for antibodies.  TPO 171 and  Ab 2413. I am being sent to an endo as it seems that I have Hashimoto's.  I am also showing Higher than normal numbers for glucose, globulin, ALT, Cholesterol, and Uric Acid.  Can anyone tell me if all this could be part of Hashimoto's or something else?

[goolarra]

I agree that all your "abnormal" labs can be the result of inadequately treated hypothyroidism, not of Hashi's per se, but of undermedication.  If you've been hypo for 20 years, and this is the first time your TPOab has been tested, it's quite likely that it's been elevated right along, just didn't know it.

Hashi's is a progressive disease.  More and more of your thyroid function is destroyed all the time.  This seldom happens on a nice, smooth slope.  Function can plateau and then take a sudden dive, which can be precipitated by stress, both physical and emotional.  Meds increases have to keep up with the decline.

If you have recent labs to post (thyroid), please do so.  Include reference ranges since those vary lab to lab and have to come from your own lab report.  We might be able to make suggestions on how your meds might be adjusted with that information.

Are you feeling hypo?

[Red_Star]

These labs can be seen with untreated or not optimally treated hypothyroidism.

Thyroid hormone is necessary for the healthy metabolism of cholesterol so high cholesterol is a common finding with hypothyroid patients.  

Hypothyroidism can cause gout.  An increased uric acid level in hypothyroidism is considered to be secondary to decreased renal (kidney) plasma flow and impaired glomerular filtration.  In other words, low thyroid hormone slows down kidney function which can lead to higher uric acid levels.

Thyroid dysfunction may perturb liver function leading to higher than normal liver enzyme levels.

Keeping your blood sugar in a normal range depends on healthy thyroid function. Low thyroid hormone can also affect your magnesium levels. Magnesium helps regulate blood sugar levels.

Common causes of globulin increase: hypochlorhydria (lack of adequate stomach acid) or liver disease (infection). Hypothyroidism slow metabolism in general which causes the parietal cells in the stomach to produce less stomach (hydrochloric) acid.