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I too have had alot of heartburn with my meds ever since the switch from synthroid. I ended up going to a gastoenterologist who sent me for an endoscopy. Said I had a hiatal hernia and esophegitis. Now I'm taking 150 mgs of Ranitidine, twice daily. I have been on many types of meds for this and not one has really taken care of the problem. Just think there's something else going on. They then sent me for a colonoscopy, which was fine. Now the are odering a small bowel series.....yeh, what ever. Looks like a fishing expidition if you ask me. I have been probed on both ends, and now I think I'll stop for awhile. My stomach problems are still the same. I just learned to live with it. My insurance company is always pushing generics on me, which they claim is the same as name brand. I don't believe them. I still think I did better on the synthroid.