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hi Peroxidase antibody

In May I had bloodwork that showed hi TSH (5.54) and hi peroxidase antibody (378.6). my pcp started me on synthroid 0.5 mcg.  Just had repeat blood work and now my TSH is lo 0.02 but my peroxidase antibody is even higher (651.1).  should my synthroid dose be altered? Do i need to see an endocrinologist instead of my PCP?
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Avatar universal
thank you for the education! i'm not really having any symptoms; i'm just worried about these high levels of antibodies causing damage.
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you are correct, thank you
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Avatar universal
may want to check that level of Levo dosage.

0.5 mcg is an EXTREMELY small amount.

I think you may mean 0.5 mg which is I believe equal to 50 mcg.

25 to 50 mcg is a common starting point for Synthroid.
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Avatar universal
TPO antibodies are not affected by the Synthroid.  The Synthroid is to offset the loss of natural thyroid hormone as your thyroid glands are being destroyed by the antibodies.  Some Hashi's patients have reported that selenium seems to reduce the level of antibodies, but that is only anecdotal info.  Also, if you consider selenium you need to do so cautiously, since it can be toxic when excessive.

Frequently hypo patients find that TSH will be suppressed when taking thyroid meds.  This does not mean that you are hyper, unless you also have hyper symptoms due to excessive thyroid meds.  It would be far better to test for the biologically active thyroid hormones, Free T3 and Free T4 (not the same as Total T3 and T4).  Free T3 largely regulates metabolism and many other body functions.  Scientific studies have also shown that FT3 correlated best with hypo symptoms, while FT4 and TSH did not correlate.  

As for your Synthroid dose being increased, that all depends on whether you are having hypo symptoms.  A good thyroid doctor will treat a hypo patient clinically by testing and adjusting Free T3 and Free T4 as necessary to relieve symptoms, without being constrained by resultant TSH levels.  Symptom relief should be all important, not just test results.  

You don't necessarily need an Endo, just a good thyroid doctor that will treat you clinically.

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