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Are you sure the doctor wants her to start taking tapazole and not one of the thyroid hormone replacement meds like Synthroid, Levoxyl or generic levothyroxine prescribed for hypOthyroidism?
There is a good chance that she may go hyper from the thyroid dieing off and dumping more hormones into her system. The RAI can cause temporary thyroiditis.
When in doubt, check the handout sheet you got from the Dr.
The thyroid doesnt abalte straight away and can take some months but just before it does die off....it dumps a huge amount of thyroid hormone which can cause hyperthyroidism and therefore beta blockers and anti-thyroid meds are wise until your wife goes hypo.
I was hypo after 5 weeks so watch for the signs.
I did have a dumping effect and it lasted approx 3 days.
In those 3 days, I took beta blockers.
Dont let your wifes TSH go over 6.0 if possible then she wont crash hypo too hard.
All the best....the worst is now over.