thyroid peroxidase level 739

[allisonroberts]

I just received my thyroid peroxidase result yesterday it was 739.  I noticed at some websites that people had high levels that were 70 or 25.   I have not came across a result as elevated as mine.  So I am a little concerned.  My ANA is positive and my TSH, T4, T3 ect results are not done yet.  What can you tell me about thyroid peroxidase?

[GravesLady]

I have read others stating a level of 1300

Autoantibodies to thyroid peroxidase (abbreviated TPOAb) are produced by the body itself. TPOAb can attack the thyroid and damage thyroid function. These antibodies are present in a high proportion of people with chronic thyroiditis. These antibodies are also present in  numbers of people with other thyroid diseases. Other autoimmune disorders such as Sjögren syndrome, lupus, rheumatoid arthritis, and pernicious anemia are sometimes positive for TPOAb. Small numbers  of people may have TPOAb show no evidence of disease. The chance of having TPOAb is greater in females and increases with age.

Thyroid antibodies  wax and wan (fluctuate up and down) and may remain positive for years, and do not provide an indication of whether the person has normal or abnormal thyroid function. Furthermore, some patients with Hashimoto's disease may have negative levels of circulating antibodies, and conversely, patients with positive levels of thyroid antibodies may never develop thyroid disease during their lifetime.

People do not get treatment for having antithyroid antibodies. They are not curable nor treatable. There is nothing that can be done to regulate antibody levels. Its the thyroid that is treated from the damages that the antibodies create.
It is possible to have the antibodies and have normal levels of thyroid hormone. People MUST get treated for abnormal levels of thyroid hormone in the body regardless of whether or not they have antithyroid antibodies.


ANA test is used when autoimmune disease is suspected particularly systemic lupus erythematosus. This test can also be performed when a patient has unexplained symptoms such as arthritis, rashes, or chest pain.  Normally there is no detectable ANA in the blood  which would produce a negative test. However, sometimes people without any specific disease may have low levels of ANA for no apparent reason.The presence of ANA in the blood may indicate: SLE (systemic lupus erythematosus), drug-induced lupus erythematosus, collagen vascular disease, myositis (inflammatory muscle disease), Sjogren's syndrome, chronic liver disease, rheumatoid arthritis, systemic sclerosis (scleroderma) and of course thyroid disease.

Thyroid levels are the prevailing diagnose and will differentiate between which autoimmune disease is present in your system. However, antibody test can relate thyroid eye disease and cancer over thyroid levels which can not.


You will have to wait and see what your levels relate

[kitcurious]

My TPO is 1238. I've seen them at 4000 here.

[allisonroberts]

Thankyou.  Your information helped a lot.