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Fatigue, pain--low PTH, vitamin D deficiency, elevated calcium
I apologize in advance for how long-winded this is, but I thought I should be thorough.
For the past six months or so, I have been terribly and increasingly fatigued; these days I am constantly tired, and have completely lost the energy to even do the things I enjoy. Prior to this beginning, I was an active, happy, and apparently healthy person. I got a good amount of exercise and had a healthy diet of fresh foods. For about a month, I have also been having joint and bone pain, which began suddenly one morning and has persisted since. The joint pain occurs in most of my joints, but is especially severe in my hands, hips, and knees. The bone pain is mostly in my legs and ribs. Conveniently, I already had an appointment scheduled to meet with my doctor about a possible enlarged lymph node under my arm found at my annual gynecological exam--though the area is visibly swollen, the doctor was unable to feel any enlarged lymph node. Additionally, I have had a slight low-grade fever daily for the past three weeks or so, with my temperature ranging from about 99.1-99.7 most of the time (my temperature is normally about 98.6 or slightly lower). I have also had an occasional dull pain beneath my ribs on the left side of my chest--it's not frequent, but it is quite painful.
I was immediately put on Indocin, vitamin d, calcium, and glucosamine and scheduled a blood test. The test, taken less than a week later, showed that I had a vitamin d deficiency (17), slightly elevated calcium level (10.4), and slightly low alkaline phosphate (32). Everything else (including differential CBC, ANA, rheumatoid factor, platelets, various vitamins, etc) came back normal. I stopped taking the calcium supplements, and increased my vitamin d supplements to 5000mg/day of D3. At this point, I was still in a lot of pain and so switched from Indocin to peroxicam. Another blood test was scheduled for the following week, which re-tested my calcium as well as my intact PTH. This test showed that my calcium had increased to 10.6 and that my PTH was very low, at <3pg/mL. The pain in my bones has decreased substantially over the past week, but my joint pain has remained steady.
At this point, my doctor was at a loss, and referred me to an endocrinologist. I won't be able to meet with this doctor for another three weeks, however, and what research on the internet I have done suggests that my problem is probably not an endocrine one, as it does not fit with hypoparathyroidism. Little is available to the layman about low PTH with vitamin d deficiency and elevated calcium. What little there is says that it is caused by either hypoparathyroidism, low magnesium, an autoimmune disorder, or cancer such as lymphoma. Considering the possibility that I am actually as sick as I feel, I was wondering if I shouldn't return to my doctor and ask for some other sort of test, such as a CT or a chest x-ray? Between the exhaustion, the pain, and the stress, I am barely able to get anything done, and am afraid that, at this rate, I will soon have to withdraw from college, and would like to avoid that if at all possible. Of course, this requires figuring out what is wrong with me.
Any thoughts at all would be immensely appreciated. Does this sound like a lymphoma or some other cancer? Like an autoimmune disease? Something else entirely? Should I ask for a chest scan, or perhaps more blood work? Thanks in advance for your thoughts.
For the past six months or so, I have been terribly and increasingly fatigued; these days I am constantly tired, and have completely lost the energy to even do the things I enjoy. Prior to this beginning, I was an active, happy, and apparently healthy person. I got a good amount of exercise and had a healthy diet of fresh foods. For about a month, I have also been having joint and bone pain, which began suddenly one morning and has persisted since. The joint pain occurs in most of my joints, but is especially severe in my hands, hips, and knees. The bone pain is mostly in my legs and ribs. Conveniently, I already had an appointment scheduled to meet with my doctor about a possible enlarged lymph node under my arm found at my annual gynecological exam--though the area is visibly swollen, the doctor was unable to feel any enlarged lymph node. Additionally, I have had a slight low-grade fever daily for the past three weeks or so, with my temperature ranging from about 99.1-99.7 most of the time (my temperature is normally about 98.6 or slightly lower). I have also had an occasional dull pain beneath my ribs on the left side of my chest--it's not frequent, but it is quite painful.
I was immediately put on Indocin, vitamin d, calcium, and glucosamine and scheduled a blood test. The test, taken less than a week later, showed that I had a vitamin d deficiency (17), slightly elevated calcium level (10.4), and slightly low alkaline phosphate (32). Everything else (including differential CBC, ANA, rheumatoid factor, platelets, various vitamins, etc) came back normal. I stopped taking the calcium supplements, and increased my vitamin d supplements to 5000mg/day of D3. At this point, I was still in a lot of pain and so switched from Indocin to peroxicam. Another blood test was scheduled for the following week, which re-tested my calcium as well as my intact PTH. This test showed that my calcium had increased to 10.6 and that my PTH was very low, at <3pg/mL. The pain in my bones has decreased substantially over the past week, but my joint pain has remained steady.
At this point, my doctor was at a loss, and referred me to an endocrinologist. I won't be able to meet with this doctor for another three weeks, however, and what research on the internet I have done suggests that my problem is probably not an endocrine one, as it does not fit with hypoparathyroidism. Little is available to the layman about low PTH with vitamin d deficiency and elevated calcium. What little there is says that it is caused by either hypoparathyroidism, low magnesium, an autoimmune disorder, or cancer such as lymphoma. Considering the possibility that I am actually as sick as I feel, I was wondering if I shouldn't return to my doctor and ask for some other sort of test, such as a CT or a chest x-ray? Between the exhaustion, the pain, and the stress, I am barely able to get anything done, and am afraid that, at this rate, I will soon have to withdraw from college, and would like to avoid that if at all possible. Of course, this requires figuring out what is wrong with me.
Any thoughts at all would be immensely appreciated. Does this sound like a lymphoma or some other cancer? Like an autoimmune disease? Something else entirely? Should I ask for a chest scan, or perhaps more blood work? Thanks in advance for your thoughts.
A related discussion, Having high PTH high anti ccp ,high RF factor was started.
MEDICAL PROFESSIONAL
Hi
Thanks for writing to the forum!
High serum calcium due to any cause can cause low PTH. This is seen in hyperparathyroidism, hyperthyroidism, Paget’s disease of the bone, PTH secreting tumors, and Vitamin D excess. Vitamin D deficiency with low PTH can cause sarcopenia or weakness of the skeletal system. You need to consult an endocrine specialist for this who is the best judge. Sometimes if the calcium and Vitamin D supplements are not taken properly or in optimum dose, it can result in erroneous lab results.
Hope this helps. Please let me know if there is any thing else and do keep me posted. Take care!
Thanks for writing to the forum!
High serum calcium due to any cause can cause low PTH. This is seen in hyperparathyroidism, hyperthyroidism, Paget’s disease of the bone, PTH secreting tumors, and Vitamin D excess. Vitamin D deficiency with low PTH can cause sarcopenia or weakness of the skeletal system. You need to consult an endocrine specialist for this who is the best judge. Sometimes if the calcium and Vitamin D supplements are not taken properly or in optimum dose, it can result in erroneous lab results.
Hope this helps. Please let me know if there is any thing else and do keep me posted. Take care!
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