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Generalized body edema or swelling can be very serious. It can be due to severe anemia, a failing heart, serious kidney disease, liver failure, electrolyte imbalance, polycystic ovary, low protein in the blood, and disorders of adrenal gland.
I understand you mother has been taking treatment. Just go through this list with your mother’s doctor and see what has been missed while testing.
Hope this helps. Please let me know if there is any thing else and do keep me posted. Take care!
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