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Pain or tightness in the back of the knee can be caused by arthritis or Bakers cysts (cystic accumulation of synovial fluid, also causes a swelling). X-rays and CT scans of the knee joint may be required. Compression of nerve, deep vein thrombosis too could be causing leg pain or it could just be overtired muscles. So if nothing is found in the knee, then these possibilities will have to be looked at by nerve conduction studies, MRIs or by duplex ultrasounds. It would be wise to consult an orthopedic specialist. Take care!
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