I recently had blood work done to test for several autoimmune disorders. Everything except ANA came back normal. I do have other symptoms which could indicate Sjogren's Syndrome, but the blood work for the disease was negative. I am a bit concerned however, because the ANA was so high, 1:1,280. I have had extreme fatigue for several months now as well as headaches, muscle/joint pain, and bloated/tender belly. I have been told in the past that I have Gilbert's Syndrome too due to elevated bilirubin. Other liver functions are normal.
Any suggestions as to what alse may cause such a high ANA? My sed rate is also normal.
Very high ANA is a feature of SLE,Sjogren’s syndrome(already ruled out in your case), scleroderma, rheumatoid arthritis, & mixed connective tissue disease.In my opinion,you should discuss these possibilities with your physician and get yourself evaluated for these.You may need various investigations like rheumatoid factor,blood tests and autoantibodies tests esp anti-centromere and anti-scl70/anti-topoisomerase antibodies.
Hope it helps.Take care and pls do keep me posted in case you have any additional doubts.Kind regards.
Thanks for the input. The odd thing with my tests is that I was also checked for ra factor, celiac, and dna, a bunch of things I can't remember (blood work results are out in the car at the moment). All of those things as well as the sed rate to indicate inflammation were all negative. I will be seeing my PCP next week to discuss all this. Was just wondering if anyone knew of any other conditions which would cause such a high ana w/out inflammation. This way I could ask my doc about extra testing if symptoms match up. What do the anti-centromere and anti-scl70/anti-topoisomerase test indicate?
Thanks so much!
Anti-centromere and anti-scl70/anti-topoisomerase test are the tests that are diagnostic of scleroderma. Scleroderma is an autoimmune disease of the connective tissue and is characterized by the formation of scar tissue (fibrosis) in the skin and organs of the body.
Hope it helps .Take care and pls do keep us posted in case you have any additional queries.Kind regards.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.