Many things can affect a PSA result beyond cancer including prostate infection/inflammation, catheter placement, colonscopy, recal examination, colitis, urinary tract infection, kidney stones, among many other reasons. I would not dismiss the tests done, but perhaps make sure you don't have a prostatitis, infection, or another reason, and then repeat the PSA one more time once any infection issues are resolved.
Dr, one more question, this PSA test results really bother me. As I mention, the newest repeat of PSA and fPSA show big difference again. PSA = 2.52, %fPSA = 8.79% (they use fPSA=0.25, but PSA=2.86). Why same blood sample, PSA test first, it was 2.52. But when test for calculate %fPSA, they use PSA=2.86 (test a bit later when test free PSA?)
Now this PSA is lower again for, 3.83 2 weeks again. SO in a bout 7 weks, PSA were like 9.6 to 3.83 to 4.01 to 2.52. What are those data telling you? data not accurate? other health reason?
IF DRE or PCA3-D (with massage of prostate) will affect PSA test results, how long after will be reasonable time to test PSA?
IF other reason caused data difference, what will be? Travel? inflammation or infection will be most like? But again, no any antibiotic or any medication has been taken during this period time.
Thank you again to read my questuons and help me out.
About PSA test, for a man in early 50s, tests for the past 4 years were 1.3-1.4 range every year, not obvious elevated. The last year tested form this range was 18 mo ago.
In Aug 2008, PSA shoot to 9.6, but was told that might be caused by DRE exam right after DRE (1 hour after).
The repeat PSA after 5 weeks, PSA=3.8; free PSA=0.4, so %fPSA?PSA=11% (seems low)
Did PCA3-D, very low, 5.8.
Repeat PSA at other Lab, 4.01, this was 2.5 days after PCA-3 test (with prostate massage).
Dr ordered repeat test for PSA and free PSA (test after 5 days after DRE again), still waiting for the results.
DRE for 2 urologist, normal with enlargement.
My question for you is, for all those data, age, no family history of prostate cancer, not an African men. If this is a patient of you, what is your advice for him at the current time? Biopsy immediately or wait or what else need to be test to exclude other factors (what will be most like after you read all those data).
Your advice is very important for me.
Thank you in advance for your time and your help!
Thank you so much to response all my questions, it is greatly appreciated. Your advices are very helpful!