If PSA elevated, about 4, but PCA3-D is very low, about 6 (>35 will be positive and high likelihood of prostate cancer or biopsy), will biopsy necessary? How to use PCA3_d with PSA to determine if biopsy will be needed?
It is important to integrate all your information to make a decision about biopsy. The absolute PSA value is important, but just as important is the trend of the PSA over time and age of the patient. PCA-3 test is a useful adjunct to these PSA values and together you make a decision with your doctor on whether a biopsy is warranted. For example, If the PSA has been 4 for a while and unchanged in an older male, then I would feel less strongly about immediate biopsy. If the PSA has been rising rapidly and/or in a younger male, despite the low PCA-3 test, I would lean towards biopsy.
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