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Fibrin Glue
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Fibrin Glue

Hi,

Can anyone give me some feed back on using fibrin glue to seal a fistula between the prostate and rectum.
Are there any possible negative side effects from this glue? Does the body absorb this or can it pose problems later?

I'm willing to try this sinse the alternative, surgery does not allways give possitive results and is rather invasive.

Any information is appreciated.

Thanks
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8 Comments Post a Comment
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Avatar_dr_m_tn
Hi,

The fibrin glue can be used for treating urethra-rectal fistulas but the success rate is approximately 60-70%.

This use of fibrin glue can be done as an outpatient procedure as a minimally invasive technique, without any significant complications.

It’s a reasonably good alternative to surgery.

I hope that helps. Take care and pls do keep me posted on how you are doing or if you have any additional doubts. Kind regards.
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647273_tn?1292094741
Thank you for the information. I have had this fistula since March of last year and it has not closed though there seems to be less irritation.
From what you have told me it sounds that it isthe reasonable thing to try. The alternative is a very invasive surgery.
The urologist agreed with me and felt that this approach should be used first.
On May 27th while I have a cystoscopy and have a suprapubic catheter replaced, he will place the fibrin glue. I hope that it works though I am concerned since the fistula has not improved since last March. I had a urethral catheter for almost a year until it was decided to place a suprapubic catheter.

Thank you,

Ron
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Avatar_m_tn
Ron, were you having prostate infection too, please help me with this if you can.  I suffered for a longtime with anal fissures  and prostate infections,  I think the cause of the infection was the fissure.  Then about ten years ago my wife told me there is  surgery for fissures,  it took me 5 years to decide on the sursery .  I couldn't take it anymore  I got the surgery done.  I am feeling much better,  but from time to time my prostate gets infected,  is that because there could be a fistula  leading to the prostate,   and if there is, how can it be found? did you also have a fissure initially?
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Avatar_m_tn
Dr. Singh,  can you please tell me how fistulas are found.  Are there fistulas that communicate between the rectum and prostate?
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647273_tn?1292094741
Hi, I discovered the fistula while I was in the hospital for a kidney infection and pneumonia. Since I have a neurogenic bladder the doctor had put a foley catheter in. I noticed that I was passing gas through the penis and catheter.

I don't know if this is relavent, but I had a resection of the bladder and prostate (TURP) in 1995. The uroligist thinks that I might have caused the fistula due to self catherization. It could also be due to a weakened area in the prostate due to the previous surgery. This is my suspician.

Since 1994 I used to come down with prostatits and UTI, kidney infections about every 3 to 4 months. This required hospital stays for 4 days up to a week at the time. After having had a urodynamics test it was discovered that I have a neurogenic bladder. From 1994 up to 2000 I kept getting these infections. I had read that they used to perform vasectomies on men having had prostate surgery to prevent the infections from settling in the testes. I used to get epididymitis and orchitis with the infections. Having opted for the vasectomy I had complications that lead to the loss of my left tesicle about a year later. From the time of the left orchiectomy up to current, I have had no infections of the right testicle.

Now I'm waiting to undergo surgery to correct the fistula since the fibrin glue did not work. I have had at least 2 minor infections since March of 2008.

I sincerely hope that you do not have the same condition as I due.

Confirmation of the fistula was made through a cystoscopy and a reverse urethrogram. The cystoscopy is passing a scope into the penis and following the urethra up to the bladder. The urethrogram involves injecting a contrast fluid into the urethra. From that pictures are taken that could show leakage of the contrast fluid into areas that it should not be.

I hope that this answers your questions. I just noticed your inquiry today.

God bless.

Ron
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Avatar_m_tn
Ron, thanks a million for your prompt answer. You don't know how much help this is to me.  I had problems more than 20 years now.  Use to get urinary track and or prostate  infections 6 or 7 times a year. After my anal fisure surgery,  now I get a massive infection yearly. I said to myself, there might still remain a  fistula from years of having anal fissures.  After I read your posts, I am convinced now there must be a possibility of residual infection  remaining.  Thanks for the info ,I will be watching for your  post, after you  get surgery for the fistula. Take care budd !
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Avatar_m_tn
Ron, have you heard of fistula plug verses the fibrin glue you had? The plug syms to be very promissing, look it up.
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647273_tn?1292094741
Hi,

As far as I know I had a plug and the fibrin glue. When I went to the bathroom the following day after feeling the urge to urinate, a small amount to urine and a grey collored plug was passed into the toilet.

I was told that the success rate for these procedures are low, about 60%. Had it been better I would have asked to repeat the procedure. The surgery is extensive and does not give any garrentee that it will be successfull. To me for my case it sounds like a loosing situation.

Since I'm currently disabled anyway, it does not make much difference to me. The only thing that we have to try is to stop further infections. After having had my catheter in since march of 2008, I sort of have become used to it. They claim that I might have caused the fistula by inserting a catheter for self catherization. Since I have a neurogenic bladder I will need to self cath again after things are healed. This poses the danger that another fistula is made. Having a suprapubic cahteter in does not seem that bad all things considered.

I will ask my urologist about the plug again on September 23, 2009 when I have another cystoscopy to see if there has been any change. I'm quite sure that the fistula has not closed at all.

All the best,

Ron
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