Pain in the upper thighs

I wondered what might be the aetiology of this, and thus the significance.

My tumour parameters are T2c, Gleason Score 3+4, PSA 58

Also, I'd be interested in your comments on a resent news clip on CNN stating that Hormone therapy may not lengthen life, and may cause bones to become brittle.

[Kevin Pho, MD]

The Gleason score is used to interpret the histology of the prostate biopsy.  It is a score from 1 to 5, with a higher score indicating a greater liklihood of non-organ confined disease and a poorer prognosis.  One number measures the growth factor, the other the degree of differentiation.  The combined score (7 in your case) would represent a moderately differentiated cancer.  

A T2c stage would indicate cancer that is confined to the prostate but has involved both sides.

Hormone therapy is associated with osteoporosis - and certainly concurrent treatment to prevent this complications should be considered (i.e. fosamax).  Hormone therapy has been shown to lengthen life in cases of advanced cancer in combination with radiation.  The benefits with its use in combination with other modalities is less clear.

You may want to discuss this with your urologist.

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
Medical Weblog:
kevinmd_b

[richbrunt]

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