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Thanks for writing in. I don’t think it is a reaction to ciprofloxacin, but could be an aggravation of the persisting infection. If it were a allergic reaction to the medicine it would be generalized, rather than local. If localized reaction is present that should be the site of injection. As you are on oral medication this is also not possible.
The most frequent side effects of ciprofloxacin include nausea, vomiting, diarrhea, abdominal pain, rash, headache, and restlessness. Hives and anaphylaxis are rarer complications to this.