Should I do a biospy

[t1234]

I have an enlarged prostrate and having a PSA test and digital exam every 6 months.  Digital exam shows no
rough spots other than prostrate is very enlarged.

My last PSA level was 4.81 on 1/18/10

Previous readings were as follows
4/30/99    3.34
10/07/08  3.86
4/08/08    3.40
10/09/07  3.87
4/10/07     3.3

Should I do a biospy; and if so, how should it be intrepreted?

[Stephen Liroff, MD]

Age is an important point to add in any discussion relating to PSA  levels. Given what you relate about the findings on your digital rectal exam, and I assume that you do not have a urine infection,  a decision would be based solely on your PSA. I would be hesitant to make a decision on the basis of a single determination and I would recommend a repeat PSA after not having had a digital rectal exam nor an orgasm for at least 3 days. If the repeat value is greater than 4, I would recommend a biopsy. If less than 4, I think that it should be repeated in 3 months and if still in the normal range, I'd repeat it in a year along with a digital rectal exam.
As to how to interpret the biopsy, I  trust that the pathologist would know how to do that.
S.A.Liroff, M.D.

[t1234]

I forget to mention I am 63 years old