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Urology (Expert Forum)
TEST FOR P27 PROTEIN ?
Questions in the Urology forum are answered by Dr. Stephen Liroff, affiliated with the Henry Ford Hospital. Topics covered include benign prostate disease, penis curvature, cystisis, kidney stones, pediatric urology, prostate, sexual dysfunction, urinary tract infections (UTI), and urological cancers.
TEST FOR P27 PROTEIN ?
by JAMES__0, Sep 07, 1998 12:00AM
How would I go about testing for a normal amount of the protein
called p27 recently mentioned as a possible cause of BPH when this protein is disabled or lost ??
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Dear James,
Protein p27 is an inhibitor of the cell cycle with potential tumor suppressor function. This means that the cells affected could reproduce more often. Decreased levels of p27 have been shown to correlate with poor outcomes in colon and breast cancer. Recently a study in the Journal of Urology out of UCLA did show a correlation between outcome and levels of p27 however this is not a widely available test. Also it ability to predict prognosis was best in stage T2 and T3 patients. First I would not worry about this test in regards to BPH. Secondly. this is a pathological test which requires that a biopsy is taken is obviously experimental.
I don’t know if we in the medical community have established its full value as a prognostic marker. I don’t know that this test is performed other than in experimental protocols. I will keep looking for more information in the upcoming literature, but in the mean time we must focus on our present knowledge about the prostate.
This information is provided for general medical educational purposes only. Please consult your physician for diagnostic and treatment options pertaining to your specific medical condition. More individualized care is available at the Henry Ford Hospital and its satellites (1 800 653-6568).
Sincerely,
HFHS M.D.-AK
*keyword:Prostate markers
