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Urology (Expert Forum)
lympho nodes
Questions in the Urology forum are answered by Dr. Stephen Liroff, affiliated with the Henry Ford Hospital. Topics covered include benign prostate disease, penis curvature, cystisis, kidney stones, pediatric urology, prostate, sexual dysfunction, urinary tract infections (UTI), and urological cancers.
lympho nodes
by oliveira, Nov 02, 1998 12:00AM
what kind of relation have positive lympho nodes and gleason's score?
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Dear Oliveira,
The Gleason’s score is a number between 2 and 10 that is assigned to a prostate cancer by the pathologist, based on his/her examination of the tissue specimen (obtained from a prostate biopsy). It gives the physicians an indication of how aggressive the cancer cell are. The higher the grade, there is less chance that the prostate cancer is still confined to the capsule of the prostate, and there is more chance that it has spread. One of the routes of spread other than local growth and extension into other tissues, is lymph node metastasis. The pelvic lymph nodes are usually the first to be involved. There is also a chance that metastasis could occur to more distant organs such as the bone. Therefore, if one compares two patients with similar sized prostate cancer(as determined on rectal exam or ultrasound biopsy), and similar PSA values, the patient with a higher Gleason’s score will have a higher chance of lymph node involvement.
I hope this answers your question, and wish you the best.
This information is provided for general medical education purposes only. Please consult your physician for diagnostic and treatment options pertaining to your specific medical condition. More individualized care is available at the Henry Ford Hospital and its satellites (1 800 653 6568).
Sincerely,
HFHS M.D.-JJ
*Keyword: prostate cancer, Gleason’s score, Lymph node metastasis
--------------------------------------------------------------------------------------------------------------------------------
Dear Oliveira,
The Gleason’s score is a number between 2 and 10 that is assigned to a prostate cancer by the pathologist, based on his/her examination of the tissue specimen (obtained from a prostate biopsy). It gives the physicians an indication of how aggressive the cancer cell are. The higher the grade, there is less chance that the prostate cancer is still confined to the capsule of the prostate, and there is more chance that it has spread. One of the routes of spread other than local growth and extension into other tissues, is lymph node metastasis. The pelvic lymph nodes are usually the first to be involved. There is also a chance that metastasis could occur to more distant organs such as the bone. Therefore, if one compares two patients with similar sized prostate cancer(as determined on rectal exam or ultrasound biopsy), and similar PSA values, the patient with a higher Gleason’s score will have a higher chance of lymph node involvement.
I hope this answers your question, and wish you the best.
This information is provided for general medical education purposes only. Please consult your physician for diagnostic and treatment options pertaining to your specific medical condition. More individualized care is available at the Henry Ford Hospital and its satellites (1 800 653 6568).
Sincerely,
HFHS M.D.-JJ
*Keyword: prostate cancer, Gleason’s score, Lymph node metastasis
