Vitamins & Supplements Community
VITAMIN D
About This Community:

Vitamins are substances that your body needs to grow and develop normally; if you have low levels of certain vitamins, you may develop a deficiency disease. Supplements can also be important to provide your body with extra nutrients depending on the activities you do. Discuss topics including vitamin deficiency, food to counter vitamin deficiency, sufficient vitamin levels, and supplements.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

VITAMIN D

I caught the radio show of DR. R.Hoffman , he stated research showed  people with low doses of Vit.D needed higher doses of pain medications
and when given higher Vit. D pain Med. decreased his patients who have Fibromyalgia he has on 5000+IU vit. D and they improved
He said anything over 2000IU should only do it under a DR. care
Related Discussions
10 Comments Post a Comment
Blank
785798_tn?1237901897
I found this on Science Daily

Low Levels Of Vitamin D In Patients With Autoimmune Disease May Be Result, Not Cause, Of The Disease

ScienceDaily (Apr. 16, 2009) — Deficiency in vitamin D has been widely regarded as contributing to autoimmune disease, but a review appearing in Autoimmunity Reviews explains that low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease and that supplementing with vitamin D may actually exacerbate autoimmune disease.
    
Authored by a team of researchers at the California-based non-profit Autoimmunity Research Foundation, the paper goes on to point out that molecular biologists have long known that the form of vitamin D derived from food and supplements, 25-hydroxyvitamin D (25-D), is a secosteroid rather than a vitamin. Like corticosteroid medications, vitamin D may provide short-term relief by lowering inflammation but may exacerbate disease symptoms over the long-term.

The insights are based on molecular research showing that 25-D inactivates rather than activates its native receptor - the Vitamin D nuclear receptor or VDR. Once associated solely with calcium metabolism, the VDR is now known to transcribe at least 913 genes and largely control the innate immune response by expressing the bulk of the body's antimicrobial peptides, natural antimicrobials that target bacteria.

Written under the guidance of professor Trevor Marshall of Murdoch University, Western Australia, the paper contends that 25-D's actions must be considered in light of recent research on the Human Microbiome. Such research shows that bacteria are far more pervasive than previously thought – 90% of cells in the body are estimated to be non-human – increasing the likelihood that autoimmune diseases are caused by persistent pathogens, many of which have yet to be named or have their DNA characterized.

Marshall and team explain that by deactivating the VDR and subsequently the immune response, 25-D lowers the inflammation caused by many of these bacteria but allows them to spread more easily in the long-run. They outline how long-term harm caused by high levels of 25-D has been missed because the bacteria implicated in autoimmune disease grow very slowly. For example, a higher incidence in brain lesions, allergies, and atopy in response to vitamin D supplementation have been noted only after decades of supplementation with the secosteroid.

Furthermore, low levels of 25-D are frequently noted in patients with autoimmune disease, leading to a current consensus that a deficiency of the secosteroid may contribute to the autoimmune disease process. However, Marshall and team explain that these low levels of 25-D are a result, rather than a cause, of the disease process. Indeed, Marshall's research shows that in autoimmune disease, 25-D levels are naturally down-regulated in response to VDR dysregulation by chronic pathogens. Under such circumstances, supplementation with extra vitamin D is not only counterproductive but harmful, as it slows the ability of the immune system to deal with such bacteria.

The team points out the importance of examining alternate models of vitamin D metabolism. "Vitamin D is currently being recommended at historically unprecedented doses," states Amy Proal, one of the paper's co-authors. "Yet at the same time, the rate of nearly every autoimmune disease continues to escalate."
Blank
1236893_tn?1394988190
Calcium, Vitamin D, and Vitamin K: Supplements that failed

Garden of Life Living Calcium Advanced (caplet, 6 per day) Only found 89.2% of claimed calcium, Vitamin D not determined, Only found 67.2% of claimed vitamin K.

Calcium and Vitamin D:Supplements that failed

IsotonixCalcium Plus (powder, 2 capfuls per day) Only found 87% of claimed calcium
Vitamin D: OK

Vitamin D and Vitamin K: Supplements that failed

DaVinciLaboratories of Vermont Vitamin K2 Plus (capsule, 1-2 per day)
Vitamin D:OK
Only found 63.4% of claimed vitamin K2 menaquinone-7

Blank
Avatar_m_tn
Read the recent research on Vitamin D.  Recommended levels have been decreased, and too high levels can be harmful, which is why the recommendation to keep in touch with your doc.
Blank
620923_tn?1405964489

  I have questions regarding reading the 3 different numbers for a vit D lab report...neone know how to read it...I know it should be 30 or better but what do the other numbers mean?

The 25 OH, D3   = 10
      25 OH D2    = 22

25 OH total     =  32

I am curious bcuz my PCP still put me on a supplement and I feel sick as a result, I am constipated and have  a major issue once a week...this is ever since I started the vit D.

I read these r symptoms of Vit D toxicity.....ne ideas???

     "selma"
Blank
Avatar_m_tn
Your PCP should be able to explain the test, but it's unlikely any PCP would recommend a dose high enough for D toxicity.  They're usually pretty conservative.  The usual recommendation up until the recent research was 1000I.Us, and that was lowered to 800 -- not a huge reduction.  People taking huge amounts are usually being dosed for specific diseases or by nutritionists and the like who believe in mega doses.  PCPs usually don't.  You do want to make sure it's D3 and natural, and check if there are any binders and fillers.  And anything that makes you sick, don't take it.  I would personally not take any supplements recommended by a PCP -- I'd take the recommendation to my best local health food store and buy something there, not from a drug store or other pharmaceutical company product because of the incorrect forms they often use (synthetic forms, common with D and E, for example, that the body can't use) and the weird fillers and binders.
Blank
620923_tn?1405964489

  Well I am taking a 1000 daily and  once a week I take a 50,000 unit capsule...the later is a RX

My daily says D3, other ingredients are soybean oil, gelatin, glycerin. My Pharmacist suggested this one for me.....

I was also wondering do I really need this if my labs r with in range...seeing that 30 and above is ok and I had 32????
Blank
Avatar_m_tn
If you get out in the sun, you don't need it, and you certainly don't seem to need the huge 50,000 dose if you have enough.  
Blank
620923_tn?1405964489

  That is what I thought...

    so, do u think some of these symptoms could be from too much Vit D?
Blank
Avatar_m_tn
Sorry, don't have a clue.  There is a recent study that recommended a lower daily dose than the 1000 being routinely used these days, so they must have found something it did in overdose.  Try googling for that study.
Blank
620923_tn?1405964489

  Thanks I will......
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Vitamins & Supplements Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank
233488_tn?1310696703
Blank
New Cannabis Article from NORTH Mag...
Jul 20 by John C Hagan III, MD, FACS, FAAOBlank
Top General Health Answerers
363281_tn?1353103243
Blank
SassyLassie
Hanmer Springs, New Zealand