i too was on phentermine and kinda hit a wall - stopped working and couldn't sleep well.. i requested meridia (big $) to replace/in addition to the phen and it gave me terrible gastric pains.
doc then had me try the phen in the morning and diethylpropion (tenuate) in evening (where i was having sleep issues). worked wonderfully. i had considered asking for phendimetrizine but i read it was a schedule 3 drug and i had read a bariatric magazine article that casually linked it to pph.
phen and diethyl still working great for last 2 months!!
These 2 medications are in the class of amphetamines and serotonin modulators which can result in serotonin syndrome.
It's a good idea to discuss any drug combinations with your doctor.
-enoch
Many physicians are not comfortable prescribing multiple weight loss medications at the same time out of concern for increased risk of side effects. Also keep in mind that phentermine is not generally recommended in the long term. It may make more sense to just stick with one of the weight loss medications to see if there are any beneficial effects. It's also a good time to think carefully about how the weight loss occurred while on the new medication.