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Two of the most important metabolic pathways in the liver are those that manufacture methionine and SAMe from homocysteine. Betaine, or trimethylglycine, is a naturally occurring substance found in many plants and animals. Betaine serves as a methyl donor in human metabolism, maintaining healthy levels of SAMe through supporting its synthesis from homocysteine, thus helping to reduce fatty infiltration of the liver.*24
Choline and Inositol support metabolism of fats by the liver.* Choline is involved in the production of bile and lipoproteins.*25,26,27 Although the body can synthesize choline in the presence of vitamin B12, folic acid, and the amino acid methionine, normal choline production may not always be adequate.*28 Diets deficient in choline may lead to undesirable changes in liver and kidney function.*29 Although inositol has not been proven to be required by humans, inositol deficiency in animals has been shown to result in an unwanted accumulation of fat i