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I had a completeComplete Complete a-z Complete allergy Complete natal Complete premium Complete senior Complete-rf hysterctomy at the age of 28 and I have been on some form of antidepressant since. It has been 11 years now. I have gained so much weight. I am currently taking effexorEffexor Effexor xr and still gaining weight. Even though it helps my moods and my depression, the weight gain is causing me to be even more depressed. I am not a big eater. I exercise and try to lose but i am unsucessful. I am trying to go off all anti depressants. The effexorEffexor Effexor xr has been the hardest to go off of for me. Has anyone had problems going off this drug and had any success and has anyone once going off been able to lose the weight.