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Depending on what diet pills your taking. Most Rx speed up your metabolism and in a result they will eat threw your pill faster. I’m on phentermine to help lose some baby weight. I notice some spottingVaginal bleeding between periods brown and red for about a week and a half in the middle of the month but I did get my period on time. I would call your pharmacist and ask, it doesn’t madder if its over the counter or not. Hope this helped!