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I dont think its much of a problem... SO many womenWomen's way have been taking them for years and years and years, but i know alot of womenWomen's way who took them and never got any types of colon cancer. If you think about it , deli meat at your local store causes cancer as well as caffein and sugar, so dont stress it. If you are concerned talk to your doc and if you have a hisotry of it then i would consider only taking it during ealry pregnancy (since thats the crucial stage for folic)