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After roughly 15 years of menopause all of a sudden I have a period. Why would this happen? I have several medical issues, so PMSPremenstrual syndrome Relieving pms just got chalked up to other illnesses. My weight gain has been just awful the last 5 years. I've gone from 100lbs to 170lbs. I am careful what I eat, but why does it not seem to matter. Depression is terrible. Have been on anti-depressants for years. Why is the depression at the point where I am very concerned. I have chronic depression, but have never felt this bad before. I have no ambition to do any thing. Is this apart of the menapause, or a combination of things?