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~~~~~~~Progesterone Levels?????~~~~~~~
by Bailee5, Aug 25, 2004 12:00AM
Yesterday I posted that my progesterone level was 9.2. I thought that was a good level and evidently my RE did too, because they encouraged me to take a hpt on Monday. But, I read yesterday that my level was not a good level and I might not have been able to have an embryo implant. So, I was wondering has anyone had a level near mine and conceived????
~Shannah~
~Shannah~
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good luck i hope you get your bfp
~nanci
If your RE was ok with it, you should be.
Good luck!
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Measuring progesterone and its metabolites. Because progesterone is the principal product of the corpus luteum, its measurement is clinically indicated to evaluate luteal phase abnormalities. For this reason, serum, urine, and salivary progesterone determinations are utilized.
Although serum progesterone is widely used in the diagnosis of LPD, there is no agreement in the cutoff level for abnormal assays, the number of assays required for diagnosis, or the timing of the test. A number of studies have demonstrated lower progesterone levels in women with "out-of-phase" endometrial biopsies,24,25 but others have noted normal progesterone levels in the presence of abnormal biopsies.26-28
These contradictory findings may be explained by the episodic release of progesterone in response to the slow pulsing of LH during the luteal phase of the cycle. Consequently, there are wide and frequent fluctuations and diurnal variations in progesterone secretion. This makes the use of a single serum progesterone determination—or even a series of single serum measurements—unreliable.
• No standard for 'normal' progesterone levels. Researchers generally have determined normal levels based on the 95% confidence limits of midluteal progesterone determinations in 2 groups of women: those with unexplained infertility and those with normal ovulatory and conception cycles. However, as mentioned earlier, the cutoff level for normal progesterone is not standard in the literature. Single midluteal serum values between 2.5 ng/mL and 15 ng/mL have been used by various investigators to distinguish normal from abnormal luteal phase levels.14,29
Using 95% confidence intervals, Landgren et al30 and Olive11 considered progesterone levels abnormal when they were less than 5 ng/mL for 5 or more days. In contrast, Wuttke and colleagues15 chose a cutoff of 8 ng/mL, based on the bimodal distribution of serum progesterone levels in normally ovulating women. In a prospective study evaluating midluteal progesterone levels in the cycle of conception, Hull et al31 found values of 10 ng/mL or more in 21 successful singleton conceptions; as a result, they proposed that such levels in the midluteal phase be considered indicative of normal luteal function.
• A range of sampling intervals proposed. To reduce the false-positive rate of a single measurement, Wuttke et al15 suggested 2 or 3 blood samples within 3 hours, since low progesterone levels are often observed prior to the occurrence of an LH pulse. Thus, the probability is high that within 3 consecutive hours an LH episode will have stimulated luteal progesterone secretion into the normal range. This approach has not been evaluated clinically. Moreover, it is likely to be time-consuming and inconvenient for the patient.
~Shannah~
Keep us posted.
I really missed you guys I am glad that I am back on. I am able toread the posts again and not feel such an overwelming sense of lose.
I am almost relieved to hear that the baby had trisomy 13. at least I can be somewhat confident if I concieve again.
Blessings to everyone. Peace Lynn
Im a concrened sister that has watched her younger sis loose 2 sets of twins at 20wks gestation. She has PCOS and fertility problems. She was put on Clomid and got pregnant not to long after. In both pregancies everything was going great until at the 20 mark and she would just start leaking amnio fluid and start contracting. There is a underlying infection that seems to be doing this. Both sets of twins were delivered by her and we had to watch them die in the incubator. They were to young and the lungs were not developed enough for survival. However she is now pregnant again and they did it on their own this time. Her fertility doctor is taking no chances and started her on progesterone injections once every 2 weeks. I'm wandering if anyone has had success with this and of course the not so successful news also. Thanks alot and god bless.
Any response would be great.
Thanks!