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Urology (Expert Forum)
TREATMENT AND PROGNOSES OF ADVANCE CARCINOMA OF BLADDER
Questions in the Urology forum are answered by Dr. Stephen Liroff, affiliated with the Henry Ford Hospital. Topics covered include benign prostate disease, penis curvature, cystisis, kidney stones, pediatric urology, prostate, sexual dysfunction, urinary tract infections (UTI), and urological cancers.
Doctor's Answer
by HFHS M.D.-BE, Oct 27, 1999 12:00AM
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Dear Dr. Dabagh,
In case of poorly differentiated bladder cancer with distant metastasis, as is the case of your father, the only treatment option is chemotherapy. This is usually with a combination regimen with methotrexate, vinblastine, doxorubicin, and cis-platin, referred to as M-VAC. The selection criteria for a patient undergoing such therapy would include good renal function, and acceptable cardiovascular health.
Usually two or three cycles of chemotherapy are given. In some series complete response in up to 25% to 30% of selected patients have been reported. Another option is combination chemotherapy and radiation.
Varying degrees of success have been reported in select group of patients up to 70%. These are small groups of patients, and therefore no definitive and final decision has been made, regarding the actual effectiveness of treatments in metastatic bladder cancer. I wish your father the best.
This information is provided for general medical education purposes only. Please consult your physician for diagnostic and treatment options pertaining to your specific medical condition. More individualized care is available at the Henry Ford Hospital and its urban campuses by calling (1 800 653 6568).
Sincerely;
HFHS-M.D. BE
* Keyword: metastatic bladder cancer
Dear Dr. Dabagh,
In case of poorly differentiated bladder cancer with distant metastasis, as is the case of your father, the only treatment option is chemotherapy. This is usually with a combination regimen with methotrexate, vinblastine, doxorubicin, and cis-platin, referred to as M-VAC. The selection criteria for a patient undergoing such therapy would include good renal function, and acceptable cardiovascular health.
Usually two or three cycles of chemotherapy are given. In some series complete response in up to 25% to 30% of selected patients have been reported. Another option is combination chemotherapy and radiation.
Varying degrees of success have been reported in select group of patients up to 70%. These are small groups of patients, and therefore no definitive and final decision has been made, regarding the actual effectiveness of treatments in metastatic bladder cancer. I wish your father the best.
This information is provided for general medical education purposes only. Please consult your physician for diagnostic and treatment options pertaining to your specific medical condition. More individualized care is available at the Henry Ford Hospital and its urban campuses by calling (1 800 653 6568).
Sincerely;
HFHS-M.D. BE
* Keyword: metastatic bladder cancer
