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STDs  (Expert Forum)
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People who don't develop HSV-2 antibodies
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University of Washington Seattle - WA
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People who don't develop HSV-2 antibodies

by ames0980, Apr 01, 2005 12:00AM
Hi,



I wrote before and you told me that a small percentage of people don't produce detectable antibody levels to be detected on the serology tests.  Why would this happen? Is it something inherent to the person or to the virus itself? Is there another way to test for infection, other than viral culture, if a person does not produce detectable antibody level?



thanks!

by H. Hunter Handsfield, M.D., Apr 01, 2005 12:00AM
Unknown why; it's probably in the biology of the test and/or the person's particular immune system and how it interacts with the virus.  It is rare.  If a person has no symptoms of HSV infection and has a negative blood test at least 3 months after the last exposure, the chance is >99% s/he is not infected and no further testing is necessary.



Good luck--  HHH, MD
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