CA-125 rise

[Hazel30]

Hi my Mom is currently under going a clinical  trial  for MORAB 003 (antibodies) for her slow rising ca-125.  She has a clear CT scan of pelvis/abdomen/chest.  Her pattern of rise  is 5-7 points every 2-4 weeks.  So its not too high and obviously slow growing cancer cells.  Now, 3 days ago when she began her clinical trial  they  drew her blood for ca-125 (47) and its up from last weeks ca-125  (34) by 13 points. So in a week it jumped up the highest in such a short time period.  BUT 2 days ago she came down with  a cold, backache, chest  congestion, headache.
So my question is could this high jump be due to the cold.  I know its not that much but looking at the patter of her ca-125 rise, the past few months it only been at the highest 7 point jump and in 2-4 week spam.  Actualy her second to last ca-125  which was drawn previously in a  two week period  went up only by 2 points (32 up to 34 in a  2 week period)  Now this 13 points  in a one week period.   We have our hopes that this small recurrence is not aggresive  and could be delayed by this trial.   I know you  can realy see the results only in one treatment but Im more concerned as to why the  rise of 13 points in a week.

THANK YOU SO MUCH
-FIANA

[daughter1948]

A related discussion, rise in CA125 was started.

[Annekathryn Goodman, M.D.]

Dear Fiana,
I wonder whether the CA 125 rise is related to the clinical trial. I do not know the details of this particular drug but many biologic therapies can cause inflammatory changes. While someone is on  he trial, it is hard to interpret the results of CA 125. Inflammation can also cause back ache.  I know that you are worrying about whether the cancer is progressing. You wont have a better sense of that until your mother has another scan.
I know it must be really hard to wait.
take care

[Hazel30]

I also wanted to  mention that its not a cold that  she has its probobly  bronchitis.  She has mild asthma and expiriencing all the symptoms of a bronchitis.

thank you

[Hazel30]

One other comment.  Today we saw her gyn/oncl and he said that he doubts the rise is due to a cold or flu.  Im very worried and becomming a bit depressed about this  again.  I was having my hopes up thinking that this is something small without any significant rise in ca-125 with good ct scans.