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Breast Cancer  (Expert Forum)
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researchermom
Answered by
Cleveland - OH
Questions posted in the Breast Cancer Forum are answered by medical professionals from The Cleveland Clinic. Topics include Breast Biopsy, Chemotherapy, Hormone Therapy, Lumps, Lumpectomy, Lymph node dissection, Lymphedema, Mammograms, Mastectomy, Radiation Therapy, Reconstruction, Self Breast Exam, and Surgery.

researchermom

by researchermom, Aug 27, 2007 10:55AM
My 45 year old daughter recently diagnosed with LCIS found during surgery to removed a ductal system with papilomatosis. Lobule excised part of nearby ductal system.  No previous breast cancer, no pregnancies. Aunt on father's side died of breast cancer around age 58. Have no history or medical info on her.  My husband's father was Ashkanazi Jew. My daughter already classified "high risk".  We have two other daughters.  Could/Should/How could my husband be genetically tested for BRCA1,2 mutations?  My daughter has selected careful followups for now.  If my husband tested negatiave, would this then be conclusive that daughters are negative?  My daughter does not want to be tested now because of insurance concerns, etc.

by Cleveland Clinic, Aug 27, 2007 12:00PM
Dear researchermom: LCIS is a factor that increases the risk for developing breast cancer.  This condition indicates an overgrowth of cells.  LCIS may increase the risk of future breast cancer by as much as 25% but many women never develop breast cancer.  There are generally three options for treating women with LCIS.  1.  Close monitoring with mammograms, clinical breast examinations and other testing as appropriate.  2.  Hormone therapy - such as tamoxifen for 5 years (directed at preventing the development of cancer) and 3.  Prophylactic mastectomy - removing the breast.  There is no absolute right or wrong answer.  Currently, most women choose one of the first two options.  In considering genetic testing, you may want to have your daughter meet with a genetic counselor who can review the family tree, assist in determining whether genetic testing (of any family member) is possible or recommended and assist with recommendations for your daughter based on her risk moving forward.  Of course, your daughter would not have to be tested but could use this information for educational purposes only.
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