Quinine Allergy

[Ronoc]

Hi there,

I believe I have an allergy to Quinine. Last time I drank tonic water, my nose and lips swelled up and a rash formed on my back. At first, I though it was the Gin that may have done this, but I recently drank tonic water and whiskey (dont ask me why...) and these allergies occured once again. Once the swelling came down, my mouth became littered with cankersores which causes eating and drinking to be very painful. I have eaten grapefruits (I have heard they contain Quinine) many times with no reaction. Does tonic water have more quinine than grapefruits? Is this why I react to tonic water and not grapefruits? What other substances contain quinine, other than malaria treatments? Any help would be much appreciated.

Thanks

[QuinineAllergic]

You're symptoms are almost identical to mine.  It took me a year and a half to pinpoint the reaction to tonic water.  When I first saw my primary doctor because of the cankersores, he originally diagnosed it as oral herpes.  After a couple other outbreaks and a quinine suspicion, I saw an allergist and the patch test and scratch test for quinine was negative.  The final test was to drink a glass of tonic.  Sure enough, 20 mins later, red swollen lips and a couple rashes elsewhere.  He was very surprised (I don't think he believed me), and said he'd never encountered this sensitivity before.  He called it a fixed drug eruption, which is fixed because the site(s) of reaction are the same spots every time.

I have found that the reactions get worse every time, to the point where it lasts a week now.  My advice is to stay far away from quinine!

As far as grapefruits, I'm not aware of any quinine in grapefruits, quick search on google suggests that it may have quinine like properties.  But I have no reaction to grapefruit.  There is a drug called Quinidine used as a heart medication.  Just tell your doctors that you have an allergy to Quinine.

Hope this helps, best of luck.

[Dr_Aparna]

Hi,
Quinine is a flavour component of tonic water, bitter lemon, and vermouth. According to tradition, the bitter taste of anti-malarial quinine tonic led British colonials in India to mix it with gin, thus creating the gin and tonic cocktail, which is still popular today in many parts of the world.
In some areas non-medical use of quinine is regulated, in the United States (by the Food and Drug Administration ) and in Germany quinine is limited to between 83-85 parts per million (83-85 mg/kg), [10] which is 0.5% to 0.25% the concentration used in therapeutic tonic.
In Canada, quinine is an ingredient in the carbonated chinotto beverage called Brio.
In the United Kingdom, Scottish company A.G. Barr's uses quinine as an ingredient in the carbonated and caffeinated beverage Irn-Bru.
In England, Australia and New Zealand, quinine is an ingredient in Schweppes and other Indian Tonic waters, at a concentration of 0.5%.
ref:http://en.wikipedia.org/wiki/Quinine
Since you are allergic to it stay away from tonics and take OTC anti-histamines to treat allergic symptoms.