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Mental Health  (Expert Forum)
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Tapering off Zoloft to begin Wellbutrin XL
Answered by
Roger Gould, M.D. - Mental Health, Wellness
Questions posted in the Mental Health forum are being answered by Dr. Roger L. Gould, author of the Mastering Stress and Depression program and affiliated with the UCLA. Department of Psychiatry. Topics covered include anger, attention deficit disorder (ADD), bipolar disorder, dementia, electroconvulsive therapy (ECT), learning disabilities, memory, obsessive compulsive disorder (OCD), panic, personality disorders, phobias, post-traumatic stress disorder (PTSD), schizophrenia, stress, transitions, and work problems.

Tapering off Zoloft to begin Wellbutrin XL

by GG4362, Oct 29, 2007 11:21AM
Hi, I was taking Zoloft (75 mg) for 4 months and requested to switch to something else due to extreme fatigue, weight gain, and other side effects.  My doc just prescribed Wellbutrin XL (150mg) to begin.  First, I am to take Zoloft at 50mg for one week then down to 25 mg for the next week before I can begin my Wellbutrin.

My first question:  is this the proper way or recommended schedule to wean off Zoloft?  Can I cut down even further and shrink the two weeks to get off Zoloft into just one?

And question two:  Is is possible to begin Wellbutrin already while still on a low dose of Zoloft?  I am already experiencing extreme mood swings at 50 mg (or maybe I'm just imaging it).

Thanks for your help!

by Roger Gould, M.D., Oct 29, 2007 04:38PM
To: gg4
It is the proper way to wean off zoloft, and you should not contract it.  But you can also start wellbutrin as you taper off, but check with your doctor to make sure he or she agrees.
Member Comments (2)

by GG4362, Oct 30, 2007 05:35PM
Thanks so much!  I truly appreciate your help!
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