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short term contact naphthylamine and bladder cancer
by kantor, Dec 02, 2007 05:52AM
I am 24 year old female junior doctor that during research two years ago was exposed to
very small amounts of 2,3-diaminonaphthalene(DAN), during Nitric Oxide
Assays.The total amount in the solution worked with was 0,06 microgram solved in
HCL. This was pippeted onto microplates on 3 different occasions, giving amax possible contact time of about 30 minutes all in all.
No spills and was wearing gloves.About a month later I had symptoms of an UTI (dysuria, slight hematuria)
that passed in a couple of days.This may very well have been a UTI, but I became petrified that this could
be linked to the DAN exposure, learning that it is a bladder carcinogen.
I have been thinking about this for years and it's scaring me a lot.
I know 2-napthalene have caused bladder cancer in industrial workers after
reviewing the litterature, but what amounts of exposure was involved?
There are levels of about 67nm of 2-napththalene in sidestream cigarette
smoke (according to what I found on the web), so would I probably have
been about the same or more expoused than someone passivly smoking a
couple of cigarettes?
I would much appreciate an answer, hopefully providing some reassurance?
Or should I be concerned, do I have a high chance of developing cancer from this?
very small amounts of 2,3-diaminonaphthalene(DAN), during Nitric Oxide
Assays.The total amount in the solution worked with was 0,06 microgram solved in
HCL. This was pippeted onto microplates on 3 different occasions, giving amax possible contact time of about 30 minutes all in all.
No spills and was wearing gloves.About a month later I had symptoms of an UTI (dysuria, slight hematuria)
that passed in a couple of days.This may very well have been a UTI, but I became petrified that this could
be linked to the DAN exposure, learning that it is a bladder carcinogen.
I have been thinking about this for years and it's scaring me a lot.
I know 2-napthalene have caused bladder cancer in industrial workers after
reviewing the litterature, but what amounts of exposure was involved?
There are levels of about 67nm of 2-napththalene in sidestream cigarette
smoke (according to what I found on the web), so would I probably have
been about the same or more expoused than someone passivly smoking a
couple of cigarettes?
I would much appreciate an answer, hopefully providing some reassurance?
Or should I be concerned, do I have a high chance of developing cancer from this?
Post Comment
Only a prolonged exposure in terms of both dosage and duration to 2,3-diaminonaphthalene(DAN) increases the risk of bladder cancer. Even then the risk of cancer is increased , there is no evidence of bladder cancer developing in all those who have had prolonged duration exposure of high doses. You can relax and do not worry too much. It would be advisable to drink plenty of water, avoid use of public washrooms and take a course of antibiotics for your UTI. You are not at an increased risk of bladder cancer from the exposure you mention you had. Relax!