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The first thing that can be done is to resect the metastatic lesions in the liver(called "metastasectomy") . Studies have shown that the five year survival rates of those who undergo liver metastasectomy are dramatically improved to more than 50% (compared to virtually 0% for those who do not undergo the procedure). Of course, the suitability of your sister for resection has to be assessed by her oncologist and surgeon. Liver metastases which are smaller in size and lesser in number generally are the best suited for resection. If liver metastases are initially unresectable, the oncologist may opt to give some chemotherapy to shrink them enough to render them resectable.
Chemotherapy for advanced colon cancer has also improved over the past years. In addition to the usual cytotoxic chemotherapy, certain biologic agents (injectable antibodies like cetuximab and bevacizumab) can now be added to the chemo drugs to greatly enhance their efficacy, without increasing toxicity. You may also wish to discuss this option with your sister's oncologist, to see if these drugs are appropriate for her.
I hope the above information helps.