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Breast Cancer: Stage 3 & 4 Community

This patient support community is for discussions relating to breast cancer, biopsy, genetics, chemotherapy, hormone therapy, lumps, lumpectomy, lymph node dissection, lymphedema, mammograms, mastectomy, radiation therapy, reconstruction, self exams, and stage 3 and 4 treatments.
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breast cancer treatment

by rajiv751, Mar 14, 2008 06:46AM
My mother is 79 years having breast cancer stage T2N0M0 and SMAC already performed i.e left breast already removed 13 days back.Biopsy report says stage 2 ductal carcinoma with no lymph involved but ER &PR are negative so hormone therapy not possible. Doctor suggests 6 round chemotherapy.Is it advisable to give chemo at this age. I am worried about the side affects of chemo at this age.Doctor has asked another test HER2 to be done.
Member Comments (7)

by Dennis MD, Mar 14, 2008 05:37PM
To: rajiv751
Hi.
I understand your concern.  There are many issues surrounding treatment of breast cancer in the elderly.  Elderly patients have other comorbid illnesses like heart disease, diabetes, renal and liver problems that can pose danger during treatment.  Thus, the risks and benefits of treatment should always be discussed before treatment is initiated.  In general, elderly patients with breast cancer should receive the same treatment as young patients.  Consider also the expected lifespan of the patient in deciding treatment.  

by rajiv751, Mar 16, 2008 12:00PM
Doctor has advised me to go for her2/neu test.Meanwhile he is planning 6 rounds of chemo.Please let me know that if we donot give chemo what will be the chances of recurence and how much time she can survive without problem.
her biopsy report say IDC(NOA) stage 2 with no lymph nodes affected, tumour size 4.0cmx3.8cmx4.0cm ,grade 3.
we are very much worried about side effects of chemo as earlier all my four sisters died of cancer(two ovarian ,one breast,one multiple myloma)

by Dennis MD, Mar 18, 2008 06:54PM
To: rajiv751
Hi.
Your mother has breast cancer stage 2, grade 3, and ER and PR negative.
As I’ve mentioned earlier, elderly patients should be managed in the same way as younger patients.  Systemic adjuvant chemotherapy may be considered for elderly patients with an estimated life expectancy of 5 years or longer.  Without giving adjuvant therapy, the risk of recurrence is high compared to giving adjuvant treatment.  
Side effects of chemotherapy are manageable.   Most of the time, supportive measures are given.

by rajiv751, Mar 26, 2008 08:57AM
Her2/neu report of my mother is negative.what that this suggests is it good or bad.pl suggest.I have put my mother on antioxidants from nutilite i.e vit E & vit C as well as proteins diet with multivitamin.

by Dennis MD, Mar 26, 2008 07:09PM
To: rajiv751
Hi.
Your mother is Her2Neu negative.  This can be considered as a good prognostic indicator.  However, the result should also be correlated with the other prognostic factors available.
You may continue giving her supplements.  
Good luck.

by rajiv751, Mar 28, 2008 03:09AM

Hi,
Dennis ,Thanks for your reply
Please let me know other prognostic factors to corelate with.Secondly let me know when and what followup test / examination to be done at what intervals..
with regards

by Dennis MD, Mar 28, 2008 11:17AM
To: rajiv751
Hi.
The other prognostic factors to consider aside from hormone receptor status and Her2Neu status are axillary lymph node involvement, tumor size, histologic grade, presence of lymphovascular invasion, and presence of proliferation indices (Ki67, MIB-1).
Patients are advised to regularly follow-up with their oncologist.  Breast self-examination should be done monthly.  Mammography can be done semiannually or annually.  Other ancillary tests (chest x-ray, ultrasound of abdomen, bone scan, PET scan) can be done on the discretion of the oncologist.
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