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Liver cancer

by lilsis551, Apr 18, 2008 11:30AM
About four weeks back, I posted about my brother being diagnosed with cirrhosis of the liver and hep c.  Now, after many, many tests and  having his belly tapped three times, he has been diagnosed with liver cancer that has spread to the blood vessels and bones.  Of course, now he is ineligible for a liver transplant.  She said he would not liver a year and that it looks like he only has months.  3 months, 6 months?  We don't know.  It's is God's hands.  We have a large family and we all realize this.  Doc prescribed Nexavar to slow down the progression of the cancer.  If he doesn't tolerate the Nexavar well, he wants not to take it.  My brother just turned 57 on April 7th.
Member Comments (2)

by Fernando Roque, MD, Apr 20, 2008 07:49AM
To: lilsis551
Hi.  I'm very sorry to hear about your brother's condition.  Nexavar (Sorafenib) can help delay the progression and spread of the cancer (from 2.8 months without treatment to 5.5 months with Nexavar) for patients with advanced liver cancer.  This drug can also prolong survival by about 3 months (10.7 months median overall survival vs. 7.9 months if no treatment is given).  There is a new study by Abou-Alfa (2007) combining the chemotherapy drug Doxorubicin with Sorafenib, with even more promising results (13.7 months overall survival with the drug combination), but these data still need to be confirmed in larger clinical trials.  

I do hope the Nexavar works with your brother.  At least it's going to buy him a little  more time which he can use to be with friends and family.

by lilsis551, May 13, 2008 09:18AM
Dr. Roque,

Thank you for replying to my post.  My brother began his treatment on Nexavar and was seemed to be tolerating it well.  On the ninth day he become began vomiting blood.  He was taken to the hospital and bleeding was stopped, and, sadly, he passed away 36 hours later.  

The doctor explained that the nausea from the Nexavar caused vomiting, which caused ruptured varices, which caused him to lose a great amount of blood.  By the time we was given more blood, his liver was no longer processing it properly and as soon as it when it, it came out in his NG tube.

It was very unexpected.  We and, I'm sure, he, thought he had more time. He is gone from us here but always in our hearts.
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