Synthroid medication

[jolagirl]

I have been taking Synthroid .075 daily for years and I feel it helps considerably. Before I started taking it I was depressed, tired, and found it hard to concentrate on my university studies. I have been gaining weight for years though despite eating properly (truthfully, as guided by a dietician). I was recently diagnosed with PCOS and (Gen) Metformin was prescribed. I began having severe upper thigh pain in my left leg within days of starting Metformin which subsided when I stopped the medication, and started again when I resumed. Pain to the point of using crutches where I have NO pain otherwise. Yet, the doctors are saying this pain is not a side effect of Metformin. I want this medication to work. Have you heard of such side effects?

Also, I take my Synthriod at night before bed. Is this advisable or is there a "prime time" to take it?

Thank you very much,

[Mark Lupo, M.D.]

Not sure about side effect of pain w/ metformin -- haven't prescribed it in years...

You can take thyroid at bedtime, most take it immediately upon waking up in the am.-- comments by GL are helpful as well.

[GravesLady]

As long as you take Synthroid hours from,  before or after, eating/foods or drinks including coffee, vitamin supplements, and other drugs.  That is to say, hours of an empty stomach. The reason it is recommended to take it or other T4 medications in the AM and not the PM, is that it can cause sleep problems due to a little boost from the initial swallowing.  The important issues is being constant.

GL,
Thyroid patient