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Depression Community
by RCA7591
Member since Feb 2007
Apr 09, 2008 11:35PM
You should've tapered down to 2.5 mg before discontinuing the BuSpar.
BuSpar is a Dopamine antagonist (blocker). Dopamine is a Catecholamine, of which there are three types: (1) Dopamine, (2) Epinephrine, and (3) Norepinephrine.
When one discontinues BuSpar abruptly without tapering the drug, Dopamine rebounds temporarily (surges). This is where the sensitivity issues arise. Dopamine has a pressor effect on the heart, and stimulates the nervous system. Nausea, headache, and sweating are common effects. They are not harmful, and they will pass within a few weeks as your body re-adapts to baseline (pre-BuSpar treatment), at which point Dopamine levels will return to normal.
The half-life of BuSpar is 3 hours, so for all practical purposes, it is out of your system. The discontinuation effects will subside gradually over the next several weeks.
In the mean time, Benadryl, 50 mg, p.r.n can be used to minimize the symptoms.
I'm not sure if this is of help to you, but I thought you would find it of value.
If you can tolerate your mood, give it some time to see if this stabilizes and your mood improves.
Good luck, and I hope you feel some improvement soon...