AMG 386/Taxol Trial

[abrite]

Have any of you been on the AMG 386/Taxol Phase II clinical trial? If so, what side-effects have you experienced and how well is the treatment working for you? Although I rarely post, I am always appreciative of your thoughts and insights. Thank-you!

[Tybear]

Hi there! I got offered this trial when I found out the last trial I was in didn't work. The reason I said no was, well, actually there were a few reasons. First, the trial is a blind study with three arms to it. There are two arms that have the AMG386 plus taxol (in varied doses) and the third arm is a placebo plus taxol. My cancer was growing fast and I didn't want to risk being in the arm that got just the taxol as I had been on it twice previously and had seen no results. The study does become un-blinded after 8 weeks (I believe) but still, at that time, 2 months was a long time to go not knowing. Also, it was weekly taxol which I meant I had to travel almost 2 hours there and back (to Toronto) to get it infused - not really my thing! The doctor's did tell me that when Taxol is given as a weekly dose that the side effects aren't as bad...no idea about the AMG386 though. What kinds of chemo have you been on in the past?
Becky

[abrite]

Hi Becky,

Thanks so  much for your response. Gosh, I can't imagine having to travel 2 hours to chemo! I have been on this study for 2 months and have seen improvement in my CA 125. Will have a CT scan soon which will probably give a better picture...no pun intended : ).  In the past I have had Taxol/Carbo/Avastin...Femara...Doxil...and now this. I had the most difficulty with the Doxil so am happy with this treatment. I still  am amazed by how different we all respond to each treatment.  The very best to you!