This patient support community is for discussions relating to advanced or metastatic prostate cancer, biopsy, bone scan, blood in urine or semen, benign prostatic hyperplasia (BPH), CT scan, cystoscopy, erectile dysfunction (ED), hormone therapy, incontinence, pain (abdomen, lower back or hip), PSA test, prostatitis, radiation therapy, rectal exam, recurrent cancer, screening, staging (tumor size, metastasis), transrectal ultrasound, watchful waiting, and urinary difficulty, burning, or urgency (leaking).
The concept of “normal” (meaning the absence of disease) is not really accurate for PSA used for prostate cancer screening. The values used as thresholds for biopsies would represent threshold values for increasing risk in which a balance of risk of procedure and odds of having disease weighs in favor of the odds of having disease. A PSA of 0.5 would have about a 7% risk of prostate cancer.
An abnormal DRE is an indication for a biopsy and does not need a high PSA to justify the decision to do so.