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Something you may not have known about tumors (and how to fight them)
by alanpvegas, Jun 09, 2008 02:41AM
Break out your diaries ladies, I am actually going to promote a chemotherapy here :)
I was looking through some of my old research files from 2006 and found information on Xyotax (a taxane) which is now called Opaxio.
Anyways I loved how they explained how this works. Essentially it's no different from the taxanes you have probablly all have taken (like Taxol, etc). We all know that tumors are hungry and they create blood vessels everywhere to feed them (well, if you didn't know...you know now lol). What they found out was that these blood vessels are not as 'healthy' (duh) as normal blood vessels. So essentially they are 'porous'...pores everywhere. But what to do with that information?
Well they created a mechanism to infiltrate these pores to deliver the taxanes right into the tumor and leave healthy tissue alone (well, maybe to at least minimize side effects). This is because normal blood vessels don't have the cancers/tumors types of blood vessels so they won't absorb Opaxio. They also found out things about estrogen (etc) and used that to enhance the drug to work better. Neat huh?
They have a neat PDF that explains this (with pictures...I love pictures), but because medhelp won't allow me to post URLs I can't add it here. Just google opaxio and you should see one for CTI (the company).
This thing has been ongoing since 2005, so it's nowhere near completion (remember, FDA trials take like 10 years if all goes well). There is a clinical trial on, but of course it's restrictive. They have info on their website.
Keep fighting everyone!
I was looking through some of my old research files from 2006 and found information on Xyotax (a taxane) which is now called Opaxio.
Anyways I loved how they explained how this works. Essentially it's no different from the taxanes you have probablly all have taken (like Taxol, etc). We all know that tumors are hungry and they create blood vessels everywhere to feed them (well, if you didn't know...you know now lol). What they found out was that these blood vessels are not as 'healthy' (duh) as normal blood vessels. So essentially they are 'porous'...pores everywhere. But what to do with that information?
Well they created a mechanism to infiltrate these pores to deliver the taxanes right into the tumor and leave healthy tissue alone (well, maybe to at least minimize side effects). This is because normal blood vessels don't have the cancers/tumors types of blood vessels so they won't absorb Opaxio. They also found out things about estrogen (etc) and used that to enhance the drug to work better. Neat huh?
They have a neat PDF that explains this (with pictures...I love pictures), but because medhelp won't allow me to post URLs I can't add it here. Just google opaxio and you should see one for CTI (the company).
This thing has been ongoing since 2005, so it's nowhere near completion (remember, FDA trials take like 10 years if all goes well). There is a clinical trial on, but of course it's restrictive. They have info on their website.
Keep fighting everyone!
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Take care,
Becky
Hi Alan.
I have read this theory and it is so promissing. But also I have a question : "If the blood vessels in tumor have openings due to retarded structure would blood itself not go through these holes and cause hemorrhaging? and how the medication know to get through and not everything else? I don't know if I understood it right.
I copied this from the website with pictures but pictures did not show here.
{{{Unlike vessels in healthy tissue , those in tumor tissue have openings that make them porous. Due to the larger size of XYOTAX compared to standard paclitaxel, the XYOTAX leaks through the pores in tumor blood vessels and is preferentially trapped and distributed to the tumor tissue}}}.
Please advise.Sunes.
it looks like the pores are smaller than the size of a normal size of blood cells/platelets, etc. I'm only assuming this because I'm looking at the size of the chemo agent itself and when they compare it to a cancer cell, it's tiny...but that's only my opinion. I'll review the data (whatever they have later) and let you all know...
You have spent so much time taking care of others, I hope you are taking care of you.
Jan
I guess it is the same finding about Vit C molecule and Glucose molecule and how they both look the same and why cancer cells "think" it's the right fuel for them where in fact it's Vitamin C molecule absorb. I have a little text in my journal about Vit C and Glucose.
Take a look if you like.
Take care, Hugs, Sunes.